Concept

Membrane nucléaire

Publications associées (126)

Development of a Photoactivatable Phosphine Probe for Induction of Intracellular Reductive Stress with Single-Cell Precision

Photoactivatable phosphines that induce intracellular reductive stress are reported. The design of these probes takes advantage of the conjugate addn. of trialkylphosphines to carbocyanine dyes, which can be reverted photochem. to produce the trialkylphosp ...

2016

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Henning Paul-Julius Stahlberg

Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals. Pyroptotic cell death has be ...

EMBO2016

Importin-beta modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Michael Graf

Soluble karyopherins of the importin-beta (imp beta) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether imp beta or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we iden ...

Elife Sciences Publications Ltd2015

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

Denis Duboule, Marion Leleu, Daniël Noordermeer, Pierre Raymond Fabre, Maxence Vieux-Rochas

Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes a ...

National Academy of Sciences2015

Electroacoustic absorption: towards room equalization in the low-frequency range

Hervé Lissek

The occurrence of standing waves in room dramatically affects the sound rendering in the low-frequency range ([20-200 Hz]), and solutions of the state-of-the-art are incapable to damp such modes over the whole low-frequency band. This talk will present a n ...

2015

Selective transport control on molecular velcro made from intrinsically disordered proteins

Sylvia Jeney

The selectivity and speed of many biological transport processes(1) transpire from a 'reduction of dimensionality'(2) that confines diffusion to one or two dimensions instead of three(3). This behaviour remains highly sought after on polymeric surfaces(4) ...

Nature Publishing Group2014

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Graham Knott, Liliane Glauser, Elpida Tsika, Darren Moore, Shi-Yan Caroline Foo, Meghna Kannan

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...

Elsevier2014

The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo

Stewart Cole, Neeraj Dhar, Claudia Sala, Ming Zhang, Gaëlle Séraphine Kolly, Naveen Kumar

The cell envelope of Mycobacterium tuberculosis contains glycans and lipids of peculiar structure that play prominent roles in the biology and pathogenesis of tuberculosis. Consequently, the chemical structure and biosynthesis of the cell wall have been in ...

Amer Soc Microbiology2014

Exploiting Enclosing Membranes and Contextual Cues for Mitochondria Segmentation

Pascal Fua, Aurélien Lucchi, Carlos Joaquin Becker, Pablo Marquez Neila

In this paper, we improve upon earlier approaches to segmenting mitochondria in Electron Microscopy images by explicitly modeling the double membrane that encloses mitochondria, as well as using features that capture context over an extended neighborhood. ...

2014

Refining Mitochondria Segmentation in Electron Microscopy Imagery with Active Surfaces

Pascal Fua, Anne Alison Jorstad

We present an active surface-based method for refining the boundary surfaces of mitochondria segmentation data. We exploit the fact that mitochondria have thick dark membranes, so referencing the image data at the inner membrane can help drive a more accur ...

Springer2014

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