Concept
Vimentine
Publications associées (24)
Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology
Mahmut Selman Sakar, Erik Mailand, Nikolaos Bouklas, Fazil Emre Uslu
Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...
2021Stabilization of overlapping biofilaments by passive crosslinkers
The formation, maintenance and reorganization of the cytoskeletal filament network is essential for a number of cellular processes. While the crucial role played by active forces generated by motor proteins has been studied extensively, only recently the i ...
2018Protein Semisynthesis Provides Access to Tau Disease-Associated Post-translational Modifications (PTMs) and Paves the Way to Deciphering the Tau PTM Code in Health and Diseased States
Hilal Lashuel, Mahmood Haj Yahya
The microtubule-associated protein Tau plays a central role in neurodegeneration and is a leading therapeutic target for the treatment of Alzheimer’s disease (AD). Several lines of evidence suggest that post-translational modifications (PTMs) regulate the ...
2018Dynamics of a flexible helical filament rotating in a viscous fluid near a rigid boundary
Pedro Miguel Nunes Pereira de Almeida Reis
We study the effect of a no-slip rigid boundary on the dynamics of a flexible helical filament rotating in a viscous fluid, at low Reynolds number conditions (Stokes limit). This system is taken as a reduced model for the propulsion of uniflagellar bacteri ...
2017Sequence and structural determinants of Tau aggregation and seeding capacity: Implications for Neurofibrillary Tangle formation and Tau toxicity in Alzheimer's disease
Despite decades of research in Alzheimerâs disease (AD), no treatment has been found to efficiently prevent or cure its progression. The microtubule binding protein Tau plays central roles in the pathogenesis of AD and is found, in the form of paired hel ...
EPFL2017