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Amino alcohols, cyclopropanes and nitriles are privileged structural motifs found in the scaffold of natural products and bioactive compounds. In addition, they are versatile building blocks in organic chemistry. The development of new and increasingly eff ...
Developing new strategies and methods to explore new dimensions of the chemical space represents an important goal for organic chemists. One particular synthetic approach that emerged in the last decades is Umpolung: the normal polarity of chemical functio ...
Enantioselective catalytic methods allowing the addition of both a nucleophile and an electrophile onto diazo compounds give a fast access into important building blocks. Herein, we report the highly enantioselective oxyalkynylation of diazo compounds usin ...
Vast amounts of phosphogypsum (PG) which is a by-product of phosphorous acid production from apatite rock using sulphuric acid, are deposited in large piles at many locations worldwide. PG materials are added at rates of the order of megatonnes (Mt) per an ...
Paul Scherrer Institute, World Resources Forum2019
Herein we report a mild synthesis of propargyl silanes from terminal alkynes. We exploit a bromonaphthyl-substituted silane as a silylmethyl electrophile surrogate, which participates in a Sonogashira reaction after an aryl-to-alkyl Pd-migration. Twenty-se ...
An approach to the synthesis of polyhydroxyazepane derivatives from sugar-based epoxyamides or epoxyalcohols, in which the total regioselective epoxide opening by nitrogen nucleophiles is the key step, is described. Thus, novel polyhydroxyazepane carboxami ...
While reinvestigating the published synthesis of OPI3, it became evident from the experiments that phosphoryl triodide may only be formed as an intermediate and that the end products of the reaction of OPCl3 with LiI are PV oxides, PI3, I2, and LiCl. This ...
A copper(I)-catalyzed vinylation of diazo compounds with vinylbenziodoxolone reagents (VBX) as partners is reported. The transformation tolerates diverse functionalities on both reagents delivering polyfunctionalized vinylated products. The strategy was su ...
An enzyme carrier is prepd. by coating 0.1-0.25 mm mineral particles with chitosan [9012-76-4] and binding it with glutaraldehyde [111-30-8], which may be reduced by NaBH4. Alternatively, an enzyme may be bonded to the chitosan layer by a carbodiimide to s ...
The reaction of Pd(cod)Cl-2 (cod = cycloocta-1,5-diene) with 1 and 2 equiv. of rac-diphenyl[2.2]paracyclophanylphosphine, rac-PPh2(C16H15), affords the dimer Pd{PPh2(C16H15)}Cl-2 (1) and the square-planar complex trans-Pd{PPh2(C16H15)}(2)Cl-2 (2), res ...
