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Mammalian Hox genes encode transcription factors that are crucial for proper morphogenesis along the various body axes. Despite their extensive structural and functional characterization, the nature of their target genes remains elusive. We have addressed ...
The Notch family of receptors is involved in a wide variety of developmental processes, including cell fate specification, cell proliferation, and cell survival decisions during cell differentiation and tissue morphogenesis. Notch1 and Notch ligands are ex ...
During limb development, coordinated expression of several Hoxd genes is required in presumptive digits. We searched for the underlying control sequences upstream from the cluster and found Lunapark (Lnp), a gene which shares limb and CNS expression specif ...
We hypothesized that the activation patterns of flexor and extensor muscles and the resulting kinematics of the forelimbs and hindlimbs during locomotion in the Rhesus would have unique characteristics relative to other quadrupedal mammals. Adaptations of ...
Anterior-to-posterior patterning, the process whereby our digits are differently shaped, is a key aspect of limb development. It depends on the localized expression in posterior limb bud of Sonic hedgehog (Shh) and the morphogenetic potential of its diffus ...
While feedback of the grasping force is necessary to manipulate objects skillfully, most Virtual Reality systems do not provide such feedback. Grasping an object is often reduced to pushing a button on the interface. This paper presents the design and real ...
The invention relates to a device and a method for measuring gait parameters. It is based on autonomous sensing units for estimation of spatio-temporal parameters during walking and uses a wavelet transform to compute the values of gait parameters from the ...
Introduction: In this study the effect of subthalamic nucleus neep brain Stimulation (STN-DBS) on the gait parameters of patients with Parkinson's disease (PD) was examined using an ambulatory gait analysis system based on miniature gyroscopes. The aim was ...
Hox genes, located at one end of the HoxD cluster, are essential for the development of the extremities of our limbs; that is, the digits. This 'collinear' correspondence is accompanied by a gradual decrease in the transcriptional efficiency of the genes. ...
Many neurophysiological and behavioural studies suggested that the lower limb endpoint might be a centrally represented variable within the gravity reference frame and effectively controlled during the locomotion. This investigation examines the effects of ...