Concept

Traitement (médecine)

Publications associées (198)

SIRT2-and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

There are currently no disease-modifying therapies for the neurodegenerative disorder Huntington's disease (HD). This study identified novel thiazole-containing inhibitors of the deacetylase sirtuin-2 (SIRT2) with neuroprotective activity in ex vivo brain ...

Cell Press2016

Hepatocyte Growth Factor-mediated satellite cells niche perturbation promotes development of distinct sarcoma subtypes

Andrea Ferrari, Michela Casanova

Embryonal Rhabdomyosarcoma (ERMS) and Undifferentiated Pleomorphic Sarcoma (UPS) are distinct sarcoma subtypes. Here we investigate the relevance of the satellite cell (SC) niche in sarcoma development by using Hepatocyte Growth Factor (HGF) to perturb the ...

Elife Sciences Publications Ltd2016

Optimization and characterization of the endogenous production of protoporphyrin IX in a yeast model

Georges Wagnières, Jaroslava Joniová, Emmanuel Louis Arthur Gerelli, Matthieu Philippe Emmanuel Zellweger

The availability of reproducible, convenient, and inexpensive model organisms able to generate predictable levels of endogenous porphyrins, including protoporphyrin IX (PpIX), is essential in photomedicine research. Saccharomyces cerevisiae produces endoge ...

Spie-Soc Photo-Optical Instrumentation Engineers2016

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Denis Gillet, Grégory François, Alain Bock

In this paper, the problem of predicting blood glucose concentrations (BG) for the treatment of patients with type 1 diabetes, is addressed. Predicting BG is of very high importance as most treatments, which consist in exogenous insulin injections, rely on ...

Elsevier2015

Numerical Assessment of Brain Stroke Follow-Up via Differential Microwave Imaging

Juan Ramon Mosig, Michael Mattes, Mina Bjelogrlic

This paper proposes a numerical assessment of brain stroke follow-up via differential Microwave Imaging. The aim is to follow the evolution of the patient’s stroke growth and location, in order to support decisions in the clinical treatment. We present a f ...

2015

Physical activity monitoring based on wearable technology combining inertial and barometric pressure sensors

Fabien Massé

Stroke, or cerebral-vascular accident is the leading cause of disabilities in the western world. It primarily affects mobility due to a degradation of principal motor functions such as balance and gait. This reduction of mobility directly impacts the spect ...

EPFL2015

Gene therapy and bioengineering for retinal diseases: what is the future?

Diego Ghezzi

Sight restoration after retinal degeneration still represents an unmet goal. Since therapeutic strategies increasingly require interdisciplinary competencies, photoreceptor degeneration is attracting several research areas, including: life science, materia ...

2015

Facial rehabilitative device based on robogami (robotic origami) platform

Jamie Paik, Amir Firouzeh

The present invention relates to a facial rehabilitative device based on Robogami (Robotic Origami) platform. The device facilitates the process of the physical therapy for the therapist, to make this process more disciplined, and to enhance the result for ...

2015

Preclinical combination therapy of the investigational drug NAMI-A(+) with doxorubicin for mammary cancer

Paul Joseph Dyson, Tina Riedel, Gianni Sava

Aim of the study The tumor metastases targeting ruthenium complex NAMI-A synergistically improves the activity of gemcitabine in combination therapies. High-throughput screening was used to identify other potential drug combinations from a library of FDA a ...

Springer2015

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Débora Bonvin, Edoardo Scherrer

Tumor vasculature is known to be poorly organized leading to increased leakage of molecules to the extravascular space. This process can potentially increase interstitial fluid pressure impairing intra-tumoral blood flow and oxygen supply, and can affect d ...

2015

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