Concept

Acidose métabolique

Publications associées (35)

Personal CO2 cloud: laboratory measurements of metabolic CO2 inhalation zone concentration and dispersion in a typical office desk setting

Inhalation exposure to pure and metabolic elevated carbon dioxide (CO2) concentration has been associated with impaired work performance, lower perceived air quality, and increased health symptoms. In this study, the concentration of metabolic CO2 was cont ...

2019

Kinetic models of metabolism that consider alternative steady-state solutions of intracellular fluxes and concentrations

Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Georgios Fengos, Tuure Eelis Hameri

Large-scale kinetic models are used for designing, predicting, and understanding the metabolic responses of living cells. Kinetic models are particularly attractive for the biosynthesis of target molecules in cells as they are typically better than other t ...

2019

Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain: An in Vivo Study by 31P-MRS

Rolf Gruetter, Lijing Xin, Özlem Ipek, Mojgan Masoodi, Nicolas Christinat, Maya Shevlyakova

Ketones represent an important alternative fuel for the brain under glucose hypo-metabolic conditions induced by neurological diseases or aging, however their metabolic consequences in healthy brains remain unclear. Here we report that ketones can increase ...

2018

Consolidated bioprocessing of lignocellulosic biomass to lactic acid by a synthetic fungal-bacterial consortium

Jeremy Luterbacher

Consolidated bioprocessing (CBP) of lignocellulosic feedstocks to platform chemicals requires complex metabolic processes, which are commonly executed by single genetically engineered microorganisms. Alternatively, synthetic consortia can be employed to co ...

2018

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C-elegans

Johan Auwerx, Laurent Mouchiroud, Pénélope Andreux, Richardus Houtkooper, Xu Wang, Norman Lionel Moullan, Adrienne Joëlle Laurence Mottis, Virginija Jovaisaite, Sabrina Bichet

Mitochondria are semi-autonomous organelles regulated by a complex network of proteins that are vital for many cellular functions. Because mitochondrial modulators can impact many aspects of cellular homeostasis, their identification and validation has pro ...

Nature Publishing Group2014

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado

Resting skeletal muscle has a preference for the oxidation of lipids compared to carbohydrates and a shift towards carbohydrate oxidation is observed with increasing exercise. Lactate is not only an end product in skeletal muscle but also an important meta ...

2014

Metabolic Disturbances in Diseases with Neurological Involvement

Degeneration of specific neuronal populations and progressive nervous system dysfunction characterize neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These findings are also reported in inherited diseases such as phenylke ...

Int Soc Aging & Disease2014

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Johan Auwerx, Eija Riitta Pirinen, Wei Li

Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects a ...

Elsevier2014

Transcriptional Coregulators: Fine-Tuning Metabolism

Johan Auwerx, Laurent Mouchiroud

Metabolic homeostasis requires that cellular energy levels are adapted to environmental cues. This adaptation is largely regulated at the transcriptional level, through the interaction between transcription factors, coregulators, and the basal transcriptio ...

Elsevier2014

In vivo metabolic studies in skeletal and cardiac muscle using ¹³C magnetic resonance spectroscopy

Josefina Adriana Maria Bastiaansen

Cardiac and skeletal muscle function relies on a continuous energy production via fatty acid metabolism and mitochondrial oxidation of pyruvate, with a fine balance between substrate delivery and utilization. Changes in metabolism are increasingly being im ...

EPFL2013

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