Concept

Breast cancer screening

Publications associées (176)

Development of bicyclic peptide Her2 binders and phage selection of alpha-helical peptide ligands

Conformationally constrained peptide ligands offer an attractive format for the development of therapeutics. They can bind with high affinity and selectivity to protein targets, they are small enough to diffuse into tissues, they can be synthesized chemica ...

EPFL2014

Sensitivity Analysis of a Bottom Reflood Simulation using Morris Screening Method

Andreas Pautz, Damar Canggih Wicaksono, Omar Zerkak

In the work presented in this paper, a sensitivity analysis using the Morris screening method was carried out for a model of the Flooding Experiment with Blocked Arrays (FEBA) separate-effect test facility. The sensitivity analysis was conducted in the con ...

2014

Inflammatory lymphangiogenesis in postpartum breast tissue remodeling

Melody Swartz

Like many cancers, mammary carcinomas use lymphatic vessels to disseminate, and numerous clinical and experimental studies have documented a strong correlation between peritumoral lymphangiogenesis and tumor dissemination. At the same time, many other fact ...

American Society for Clinical Investigation2014

Structural and Mechanistic Paradigm of Leptin Receptor Activation Revealed by Complexes with Wild-Type and Antagonist Leptins

Henning Paul-Julius Stahlberg

Leptin activates its cognate receptor (LR) to regulate body weight and metabolically costly processes, such as reproduction and immune responses. Despite such benevolent pleiotropy, leptin-mediated signaling has been implicated in autoimmune diseases and b ...

Elsevier BV2014

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

Patrick Fraering

The goal of targeted cancer therapies is to specifically block oncogenic signalling, thus maximising efficacy, while reducing side-effects to patients. The gamma-secretase (GS) complex is an attractive therapeutic target in haematological malignancies and ...

Springer2014

An approximate single fluid 3-dimensional magnetohydrodynamic equilibrium model with toroidal flow

Olivier Sauter, Jonathan Graves, Wilfred Anthony Cooper, Trach-Minh Tran, David Pfefferlé, Jonathan Marc Philippe Faustin, Daniele Brunetti, Madhusudan Raghunathan

An approximate model for a single fluid three-dimensional (3D) magnetohydrodynamic (MHD) equilibrium with pure isothermal toroidal flow with imposed nested magnetic flux surfaces is proposed. It recovers the rigorous toroidal rotation equilibrium descripti ...

Institute of Physics2014

Eigensensing And Deconvolution For The Reconstruction Of Heat Absorption Profiles From Photoacoustic Tomography Data

Dimitri Nestor Alice Van De Ville, Thierry Blu, Zafer Dogan

Photoacoustic tomography (PAT) is a relatively recent imaging modality that is promising for breast cancer detection and breast screening. It combines the high intrinsic contrast of optical radiation with acoustic imaging at submillimeter spatial resolutio ...

Ieee2013

Does Cancer Start in the Womb? Altered Mammary Gland Development and Predisposition to Breast Cancer due to in Utero Exposure to Endocrine Disruptors

Cathrin Brisken

We are now witnessing a resurgence of theories of development and carcinogenesis in which the environment is again being accepted as a major player in phenotype determination. Perturbations in the fetal environment predispose an individual to disease that ...

Springer Verlag2013

Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast

Cathrin Brisken, Georgios Sflomos, Ayyakkannu Ayyanan, Maryse Fiche, Tamara Tanos, Maria Gutierrez Najera

Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ. Yet, their respective roles and the mechanisms underlying their action in the human breast are unclear. Receptor activator of nuclear factor ...

American Association for the Advancement of Science2013

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

Cathrin Brisken

Abstract | Understanding the biology of the breast and how ovarian hormones impinge on it is key to rational new approaches in breast cancer prevention and therapy. Because of the success of selective oestrogen receptor modulators (SERMs), such as tamoxife ...

Nature Publishing Group2013

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