Concept

Cisplatine

Publications associées (74)

A mass spectrometric and molecular modelling study of cisplatin binding to transferrin

Paul Joseph Dyson, Claire Samantha Allardyce

A combination of mass spectrometry, UV/Vis spectroscopy and molecular modelling techniques hove been used to characterise the interaction of cisplatin with human serum transferrin (Tf). Mass spectrometry indicates that cisplatin binds to the hydroxy functi ...

2005

Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: Influence of the ligands on drug efficacies and uptake

Paul Joseph Dyson, Wee Han Ang

A series of trans-platinum(IV) complexes with functionalized aromatic carboxylate ligands, cis,cis,trans-Pt(NH3)2Cl2(CO2C6H4R)2 (R = H (3), p-vinyl (4), p-methoxy (5), p-iodo (6), ...

2005

Cisplatin binding to DNA oligomers from hybrid Car-Parrinello/molecular dynamics simulations

Ursula Röthlisberger, Paolo Carloni

Cisplatin is widely used in clinic treatment against a variety of cancer diseases. It binds to two adjacent guanine residues and induces a bend in the DNA double helix. It is believed that cell death is induced upon binding of proteins, which recognize pla ...

2004

Reactivity and fluxionality of late transition metal cluster compounds

Zoltan Beni

The first part of this work deals with oxidative addition reactions of the triangulo platinum cluster [Pt3(μ-CO)3(PCy3)3]. Reactions with the electrophilic molecules ICH2CN and X2 (X = I and Br) and with the weakly polar reagent Ph3SnH have been studied. A ...

EPFL2004

Recent developments in the isonitrile-based multicomponent synthesis of heterocycles

Jieping Zhu

A review. Although the synthesis of beta -lactams by means of tethered Ugi reactions was known since the early 1960s, the 1995 report from Ugi's group could be regarded as a turning point in the development of novel multicomponent reactions (MCRs) for hete ...

2003

Determination of drug binding sites to proteins by electrospray ionisation mass spectrometry: the interaction of cisplatin with transferrin

Paul Joseph Dyson, Claire Samantha Allardyce

Cisplatin, CiS-[PtCl2(NH3)(2)], is known to bind to human serum transferrin, but the binding site remains a matter of some debate. Electrospray ionisation mass spectrometry has been used to characterise the interaction of cisplatin with transferrin. The st ...

2002

Inductively coupled plasma mass spectrometry to identify protein drug targets from whole cell systems

Paul Joseph Dyson, Claire Samantha Allardyce

Proteins from cisplatin treated bacterial cells were partially separated by 1D polyacrylamide gel electrophoresis and analysed by laser ablation inductively coupled plasma mass spectrometry; using peptide fingerprinting methods central to proteomics, the b ...

2001

The reaction of alkenes with triangulo-clusters [Pt3(m-CO)3(PR3)3]

Gabor Laurenczy, Raymond Roulet

The reactions of the cluster complexes [Pt-3(mu -Co)(3)L-3], where L = PPh3 1a, PPh(2)Bz 1b and PCy3 1c, with activated mono-olefins have been studied under preparative and equilibrium conditions. At low temperature the olefins react quantitatively giving ...

2001

Total synthesis and conformational studies of hapalosin, N-desmethylhapalosin and 8-deoxyhapalosin

Jieping Zhu

Hapalosin I (R1 = Me, R2 = OH), a 12-membered cyclic depsipeptide possessing MDR-reversing activity, and its analogs, N-desmethylhapalosin I (R1 = H, R2 = OH) and 8-deoxyhapalosin I (R1 = Me, R2 = H), have been synthesized using macrolactamization as an im ...

1999

Space-charge influenced injection model for conduction in Pb(ZrxTi1-x)O-3 thin films

Alexander Tagantsev, Igor Stolichnov

A comprehensive study of: leakage conduction in Pb(ZrxTi1-x)O-3 films with Pt electrodes is carried out. The conduction properties of films prepared in different ways (sol-gel coating, metalorganic chemical vapor deposition, sputtering) were studied by usi ...

1998

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