Concept
Sperm motility
Publications associées (16)
Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
Pierre Gönczy, Fernando Romero Balestra
Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...
GENETICS SOCIETY AMERICA2023Centriole foci persist in starfish oocytes despite Polo-like kinase 1 inactivation or loss of microtubule nucleation activity
Pierre Gönczy, Nils Kalbfuss, Marie Juliette Ségolène Pierron
Centrioles must be eliminated or inactivated from the oocyte to ensure that only the two functional centrioles contributed by the sperm are present in the zygote. Such removal can occur during oogenesis, as in Drosophila, where departure of Polo kinase fro ...
2020Microbial life in porous systems
Microbial life in porous systems dominates the functioning of numerous ecosystems, ranging from stream sediments to soils. While these environments are characterized by structures that vary spatially over orders of magnitude, the traditional research focus ...
EPFL2019Transcription Factor USF1 Is Required for Maintenance of Germline Stem Cells in Male Mice
A prerequisite for lifelong sperm production is that spermatogonial stem cells (SSCs) balance self-renewal and differentiation, yet factors required for this balance remain largely undefined. Using mouse genetics, we now demonstrate that the ubiquitously e ...
ENDOCRINE SOC2019Mutations in the polyglutamylase geneTTLL5, expressed in photoreceptor cells and spermatozoa, are associated with cone-rod degeneration and reduced male fertility
Hereditary retinal degenerations encompass a group of genetic diseases characterized by extreme clinical variability. Following next-generation sequencing and autozygome-based screening of patients presenting with a peculiar, recessive form of cone-dominat ...
Oxford University Press2016Chemical Genetic Screen Identifies Natural Products that Modulate Centriole Number
Kai Johnsson, Pierre Gönczy, Michele Graciotti, Zhou Fang
Centrioles are microtubule-based organelles found in most eukaryotic cells and that are critical for the formation of cilia and flagella, as well as of centrosomes in animal cells. The number of centrioles must be strictly regulated in proliferating cells ...
Wiley-Blackwell2016Mechanisms of differential centriole inheritance in C. elegans
Centrosomes are the principal microtubule organizing center (MTOC) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated to ensure bipolar spindle formation and thus fait ...
EPFL2014SAS-1 Is a C2 Domain Protein Critical for Centriole Integrity in C. elegans
Pierre Gönczy, Graham Knott, Simon Blanchoud, Lukas von Tobel, Tamara Mikeladze-Dvali
Centrioles are microtubule-based organelles important for the formation of cilia, flagella and centrosomes. Despite progress in understanding the underlying assembly mechanisms, how centriole integrity is ensured is incompletely understood, including in sp ...
Public Library of Science2014Effects of ploidy and sex-locus genotype on gene expression patterns in the fire ant Solenopsis invicta
Chitsanu Khurewathanakul, Oksana Riba Grognuz, Laurent Keller
Males in many animal species differ greatly from females in morphology, physiology and behaviour. Ants, bees and wasps have a haplodiploid mechanism of sex determination whereby unfertilized eggs become males while fertilized eggs become females. However, ...
Royal Soc2014Analysis of centriole elimination during C. elegans oogenesis
Pierre Gönczy, Graham Knott, Petr Strnad, Lukas von Tobel, Tamara Mikeladze-Dvali
Centrosomes are the principal microtubule organizing centers (MTOCs) of animal cells and comprise a pair of centrioles surrounded by pericentriolar material (PCM). Centriole number must be carefully regulated, notably to ensure bipolar spindle formation an ...
2012