Publications associées à Cancer immunology

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

Didier Trono, George Coukos, Marion Leleu, Evaristo Jose Planet Letschert, Markus Müller, Florian Huber, Laia Simo Riudalbas, Delphine Yvette L Grun, Ioannis Xenarios, Lin Zhang, Alexandre Harari, Marion Arnaud

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable of mediating T cell-based tumor rejection still face important challenges. Recent studies suggest that non-canonical tumor-specific HLA peptides derived from annotated ...

2020

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Pedro Romero, Amaia Martinez Usatorre

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

2020

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Michele De Palma, Alan Nicolas Thierry Guichard, Nicolo Rigamonti, Daniela Pais Ferreira

Cancer immunotherapies are increasingly combined with targeted therapies to improve therapeutic outcomes. We show that combination of agonistic anti-CD40 with antiangiogenic antibodies targeting 2 proangiogenic factors, vascular endothelial growth factor A ...

2020

Engineering dendritic cell vaccines to improve cancer immunotherapy

Michele De Palma, Caleb Ricardo Perez

At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenv ...

Springer2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Michele De Palma, Romain Hamelin, Bruno Torchia, Chiara Cianciaruso, Sina Nassiri, Tim Beltraminelli

Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichm ...

2019

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

Bruno Lemaitre, Anna Dostalova

Antimicrobial peptides (AMPs) are small cationic molecules best known as mediators of the innate defence against microbial infection. While in vitro and ex vivo evidence suggest AMPs' capacity to kill cancer cells, in vivo demonstration of an anti-tumour r ...

ELIFE SCIENCES PUBLICATIONS LTD2019

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

Jeffrey Alan Hubbell, Melody Swartz, Seung Tae Lee, Lambert Charles François Potin, Jun Ishihara, Kazuto Fukunaga, Michal Mateusz Raczy

Cancer immunotherapy with immune checkpoint inhibitors (CPIs) and interleukin-2 (IL-2) has demonstrated clinical efficacy but is frequently accompanied with severe adverse events caused by excessive and systemic immune system activation. Here, we addressed ...

AMER ASSOC ADVANCEMENT SCIENCE2019

Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives

Filipe Amândio Brandão Sanches Vong Martins

Immune checkpoint inhibition (ICI) became one of the major breakthroughs in cancer treatment over the past decade and entered into therapy within standard oncohematology practice. ICI has demonstrated impressive response rates as salvage therapy in relapse ...

2019

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Cancer immunology

Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes

Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Engineering dendritic cell vaccines to improve cancer immunotherapy

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives

Role of Activin-A signaling in melanoma

Graph Chatbot

Chattez avec Graph Search

Engineering dendritic cell vaccines to improve cancer immunotherapy

Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma

Immune Checkpoint Inhibition in Classical Hodgkin Lymphoma: From Early Achievements towards New Perspectives

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death in Drosophila

Role of Activin-A signaling in melanoma

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles