Concept
PLK1
Publications associées (27)
Centriole foci persist in starfish oocytes despite Polo-like kinase 1 inactivation or loss of microtubule nucleation activity
Pierre Gönczy, Nils Kalbfuss, Marie Juliette Ségolène Pierron
Centrioles must be eliminated or inactivated from the oocyte to ensure that only the two functional centrioles contributed by the sperm are present in the zygote. Such removal can occur during oogenesis, as in Drosophila, where departure of Polo kinase fro ...
2020Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning
Pierre Gönczy, Coralie Busso, Benita Wolf
Zika virus (ZIKV) causes congenital microcephaly. Although ZIKV can impair cell cycle progression and provoke apoptosis, which probably contributes to disease aetiology through depletion of neural progenitor cells, additional cellular mechanisms may be imp ...
Royal Society, The2017Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies
Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death. Whereas previous reports suggested that Plk1 ...
Wiley-Blackwell2016