Publications associées à Hématome rétroplacentaire

Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity

Jeffrey Alan Hubbell, Melody Swartz, Lambert Charles François Potin, Martina Damo, Jun Ishihara, Kazuto Fukunaga

CD40 is an immune costimulatory receptor expressed by antigen-presenting cells. Agonistic anti-CD40 antibodies have demonstrated considerable antitumor effects yet can also elicit serious treatment-related adverse events, such as liver toxicity, including ...

AMER ASSOC CANCER RESEARCH2018

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Jeffrey Alan Hubbell, Melody Swartz, Hans Mattias Larsson, Lambert Charles François Potin, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga

Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...

Amer Assoc Advancement Science2017

Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction

Yohan Van de Looij, Maxime Olivier Baud

Fetal growth restriction (FGR) is a major complication of human pregnancy, frequently resulting from placental vascular diseases and prenatal malnutrition, and is associated with adverse neurocognitive outcomes throughout life. However, the mechanisms link ...

Wiley-Blackwell2016

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

Lionel André Maurizi

BACKGROUND: Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and invitro studies have shown that nan ...

Nat Inst of Environ Health Sciences / The National Institute of Environmental Health Sciences (NIEHS)2015

The evolution of lncRNA repertoires and expression patterns in tetrapods

Anamaria Necsulea, Magali Soumillon

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative an ...

Nature Publishing Group2014

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Federico Tortelli, Stéphanie Elisabeth Metzger, Jeffrey James Rice

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

Amer Assoc Advancement Science2014

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Simona Frateschi, Friedrich Beermann, Roch-Philippe Charles, Aline Dousse

The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic lethality. ...

Public Library of Science2013

Proteolytic Processing Regulates Placental Growth Factor Activities

Jeffrey Alan Hubbell, Stéphanie Elisabeth Metzger, Martin Ehrbar, Manuel Koch

Placental growth factor (PlGF) is a critical mediator of blood vessel formation, yet mechanisms of its action and regulation are incompletely understood. Here we demonstrate that proteolytic processing regulates the biological activity of PlGF. Specificall ...

Amer Soc Biochemistry Molecular Biology Inc2013

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Hématome rétroplacentaire

Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity

A KRABsody for Embryo-Placental Development

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

The evolution of lncRNA repertoires and expression patterns in tetrapods

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Proteolytic Processing Regulates Placental Growth Factor Activities

Proangiogenic Factor PlGF Programs CD11b(+) Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

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Chattez avec Graph Search

A KRABsody for Embryo-Placental Development

Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Transcriptomic regulations in oligodendroglial and microglial cells related to brain damage following fetal growth restriction

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

The evolution of lncRNA repertoires and expression patterns in tetrapods

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

The Channel-Activating Protease CAP1/Prss8 Is Required for Placental Labyrinth Maturation

Proteolytic Processing Regulates Placental Growth Factor Activities

Proangiogenic Factor PlGF Programs CD11b(+) Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors