Concept

Ostéogenèse

Publications associées (66)

Fatigue as the missing link between bone fragility and fracture

Dominique Pioletti, Vincent Stadelmann, Claire Acevedo

The prevention of fragility fractures in bone—pathologic fractures resulting from daily activity and mostly occurring in the elderly population—has been a long-term clinical quest. Recent research indicating that falls in the elderly might be the conse- qu ...

2018

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr

The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...

Cognizant Communication Corp2017

Cement stress predictions after anatomic total shoulder arthroplasty are correlated with preoperative glenoid bone quality

Alexandre Terrier, Alain Farron, Raphaël Rodolphe Obrist

Hypothesis: We hypothesized that biomechanical parameters typically associated with glenoid implant failure after anatomic total shoulder arthroplasty (aTSA) would be correlated with preoperative glenoid bone quality. Methods: We developed an objective aut ...

Elsevier2017

OVERCORRECTED GLENOID IMPLANTS TO AVOID RECURRENT SUBLUXATION AFTER TOTAL SHOULDER ARTHROPLASTY: A PATIENT-SPECIFIC FINITE ELEMENT ANALYSIS

Sandro Andrin Bergamin

Hypothesis: Total shoulder arthroplasty is an efficient treatment to osteoarthritis but has a relatively high failure rate. One of the main causes were found to be glenoid loosening associated with off-center loadings. An implant with an overcorrected desi ...

2017

Mechanical and biochemical characterisation of a articular cartilage based dECM hydrogel

Quentin Vermeire

In this study we present a photocrosslinkable and layerable hydrogel based on decellularized extracellular matrix (dECM) intended for in vitromodels of cartilage tissue formation. dECM can provide cellular environments that are close to the native tissue s ...

2016

In vivo mechanical loading combined with cell therapy in a bone tissue engineering scaffold

Tanja Cloé Hausherr

Bone defects generate a worldwide high demand for bone repair and reconstruction. The incidence of bone defect repair in our aging society is expected to increase in the next decades. As bone auto- and allografting solutions often suffer from limited suppl ...

EPFL2016

Biomechanical Role of Bone Anisotropy Estimated on Clinical CT Scans by Image Registration

Alexandre Terrier, Adeliya Latypova, Elham Taghizadeh, Philippe Büchler

Image-based modeling is a popular approach to perform patient-specific biomechanical simulations. Accurate modeling is critical for orthopedic application to evaluate implant design and surgical planning. It has been shown that bone strength can be estimat ...

Springer Verlag2016

A numerical model to reproduce an experimental design to detect strain in cement

Christina Maria Bauer

An experimental set-up consisting of a loading device inserted in a μCT scanner was numerically simulated to predict the strain at the bone-implant interface of the scapula after applying various loading conditions. The aim of the project was to determine ...

2016

Characterization of bone progenitor cells after GFP lentivirus transfection

Axelle Deirdre Eve Justafré, Tanja Cloé Hausherr

Several treatments have been developed for treating bone fractures as they are very common events. Amongst other new strategies, synthetic bone substitutes present a very high potential therapy because they lower the risk of infection and rejection. Moreov ...

2015

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