Concept

Ostéogenèse

Publications associées (66)

Osteoconductive surfaces generated from peptide functionalized poly(2-hydroxyethyl methacrylate-co-2-(methacryloyloxy)ethyl phosphate) brushes

Modification of bone implant materials with biofunctional surfaces that facilitate osteoblast adhesion and promote matrix mineralization is an attractive strategy to improve osseointegration. This manuscript discusses the preparation and properties of RGD ...

Royal Soc Chemistry2012

Prediction of spatio-temporal bone formation in scaffold by diffusion equation

Dominique Pioletti, Arne Christian Vogel, Lalaonirina Rakotomanana Ravelonarivo, Alireza Roshan Ghias

Developing a successful bone tissue engineering strategy entails translation of experimental findings to clinical needs. A major leap forward towards this goal is developing a quantitative tool to predict spatial and temporal bone formation in scaffold. We ...

2011

In vivo loading increases mechanical properties of scaffold by affecting bone formation and bone resorption rates

Dominique Pioletti, Alireza Roshan Ghias

A successful bone tissue engineering strategy entails producing bone-scaffold construct with adequate mechanical properties. Apart from the mechanical properties of the scaffold itself, the forming bone inside the scaffold also adds to the strength of the ...

2011

Laser-Doppler flowmetry at large interoptode spacing in human tibia diaphysis: Monte Carlo simulations and preliminary experimental results

Dimitri Nestor Alice Van De Ville

Laser-Doppler flowmetry (LDF) is an outstanding tool to monitor blood flow in a continuous and non-invasive way. In this work, we study LDF at large interoptode spacing applied to a human bone model (i.e. tibia diaphysis). To that aim, we first performed a ...

Institute of Physics2011

Regulation of proliferation and differentiation of human fetal bone cells

Dominique Pioletti

During the last decade, extensive research has been performed in the field of orthopedic medicine to develop cell-based therapies for the restoration of injured bone tissue. We previously demonstrated that human primary fetal bone cells (HFBCs) associated ...

2011

Surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold

Dominique Pioletti, Alireza Roshan Ghias

The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...

Wiley-Blackwell2011

Biomechanical Aspects of Osteogenesis in Load-Bearing Tissue Engineering Scaffolds

Alireza Roshan Ghias

There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...

EPFL2011

In vivo assessment of local effects after application of bone screws delivering bisphosphonates into a compromised cancellous bone site

Dominique Pioletti, Alireza Roshan Ghias

Background: The primary stability of cancellous screw is difficult to obtain in bone of compromised quality and failure of screw fixation is common. To overcome this problem, it is proposed to locally deliver bisphosphonate from the screw An in vivo valida ...

Elsevier2011

Effects of Tissue-Level Ductility on Trabecular Bone Strength

Frédéric Edouard Juillard

Osteoporosis is one of the most common skeletal diseases that lead to an accelerated bone loss due to an imbalance in bone turnover. This low bone mass and degraded bone microarchitecture cause a reduction in mechanical properties and an associated increas ...

2011

Effects of morphogen advection on osteogenic differentiation of hMSCs using a microfluidic device with 2D micro patterned cell colonies

Dominique Pioletti, Alexandre Terrier, Miguel Gortchacow

It has been established that primary stability of femoral stems is a determinant of the clinical success of cementless total hip arthroplasty. Excessive interface micromotions may lead to a peri-implant fibrous tissue formation resulting in aseptic looseni ...

2010

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