Concept
Prophase
Publications associées (77)
Chromatin organization in red triangles
This journal club by Elisa Oricchio highlights two studies published in 2012, which used chromatin conformation capture methods to detect the formation of self-interacting chromatin regions, known as topologically associating domains (TADs). ...
NATURE PORTFOLIO2023Whole genome doubling promotes tumorigenesis through loss of chromatin segregation and compartment repositioning
Whole genome doubling (WGD) events are drivers of genetic innovation across vertebrate evolution. While generally detrimental to mammalian organisms, WGDs are crucial in the development of various plants and fungi, as well as for the terminal differentiati ...
EPFL2023Dynamic Chromatin Invasion and Remodeling by the Transcription Factor Rap1
Pioneer transcription factors (PTF) are a subset of transcription factors with nucleosome-binding properties allowing them to bind specific sequences in condensed chromatin. Although the biological functions of PTFs including target genes and epigenetic ch ...
EPFL2021