Concept

Expansion planétaire de l'Homme moderne

Publications associées (33)

Bacterial diversity dominates variable macrophage responses of tuberculosis patients in Tanzania

The Mycobacterium tuberculosis complex (MTBC) comprises nine human-adapted lineages that differ in their geographical distribution. Local adaptation of specific MTBC genotypes to the respective human host population has been invoked in this context. We aim ...

Nature Portfolio2024

City, State, Transnational Space

Garance Clément

This chapter takes stock of contemporary migration by breaking with a few myths and by distinguishing between interregional and international migration. It shows how new research paradigms have relativized the importance of the state as the preferred frame ...

ISTE Wiley2023

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Xiaoxu Li

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

A platform for experimental precision medicine: The extended BXD mouse family

Johan Auwerx, Evan Graehl Williams

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely ...

CELL PRESS2021

Population Genomics of Mycobacterium leprae Reveals a New Genotype in Madagascar and the Comoros

Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh, Thyago Leal Calvo

Human settlement of Madagascar traces back to the beginning of the first millennium with the arrival of Austronesians from Southeast Asia, followed by migrations from Africa and the Middle East. Remains of these different cultural, genetic, and linguistic ...

2020

Géohistoire de l'Albanie moderne. Une lecture des recensements de 1918 à 2011.

Alain Nicolas Jarne

In this thesis, an original database is constituted, described and exploited in a geohistorical perspective, containing the registration of the population at the local level for the fifteen censuses conducted in Albania between 1918 and 2011. The precision ...

EPFL2020

Global maps of travel time to healthcare facilities

Access to healthcare is a requirement for human well-being that is constrained, in part, by the allocation of healthcare resources relative to the geographically dispersed human population(1-3). Quantifying access to care globally is challenging due to the ...

2020

Adaptation of waterborne echovirus to warm habitats enhances disinfection resistance

Tamar Kohn, Anna Carratala Ripolles, Virginie Bachmann

Because of their high mutation rate, enteric virus populations excreted from a host are not clonal, but rather consist of a mutant cloud with many different genetic variants. Among these variants, the susceptibility to environmental stressors (e.g., temper ...

2019

The Demographic History of African Drosophila melanogaster

Jeffrey David Jensen, Adamantia Kapopoulou, Susanne Petra Pfeifer, Stefan Jean Laurent

As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophila melanogaster remains as an important research question. This owes both to the inherent interest in charac ...

OXFORD UNIV PRESS2018

Genome-wide SNP profiling of worldwide goat populations reveals strong partitioning of diversity and highlights post-domestication migration routes

Stéphane Joost, Estelle Rochat, Elia Vajana

Background: Goat populations that are characterized within the AdaptMap project cover a large part of the worldwide distribution of this species and provide the opportunity to assess their diversity at a global scale. We analysed genome-wide 50K single nuc ...

BMC2018

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