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In the framework of this thesis molecular nanostructures have been engineered on surfaces and are characterized using a variety of techniques. Two types of molecules have been used: carbon nanotubes (CNT) and 4-[trans-2-(pyrid-4-yl-vinyl)] benzoic acid (PV ...
Institut fur Pflanzengenetik und Kulturpflanzenforschung (IPK), Corrensstr. 3, D-06466 Gatersleben, Germany. A complex mixture of fatty acid-derived aldehydes, ketones, and alcohols is released upon wounding of the moss Physcomitrella patens. To investigat ...
Detection of viral nucleic acids is central to antiviral immunity. Recently, DAI/ZBP1 (DNA-dependent activator of IRFs/Z-DNA binding protein 1) was identified as a cytoplasmic DNA sensor and shown to activate the interferon regulatory factor (IRF) and nucl ...
In photodynamic therapy (PDT), excitation of a drug by light leads to a cascade of biochemical processes that can cause closure of blood vessels. It has been observed clinically that significant short-term leakage from the irradiated vasculature can occur ...
Anachelin, a complex secondary metabolite isolated from Anabaena cylindrica, possesses an unusual structure combining polyketide, peptide and alkaloid building blocks. This natural product was postulated to act as siderophore with catecholate and salicylat ...
Mitsunobu displacement of (-)-(1S,4R,5S,6S) -4,5,6-tris{[(tert-butyl)dimethylsilyl] oxy}cyclohex-2-en-1-ol ((-)-12; a (-)-conduritol-F derivative) with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one (16) provided a 5a-carba-beta-D-pyranoside (+)-17 that was conve ...
The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta (or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome proliferators, including fibrates and fatty acids, activate the transcriptional ...
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthet ...
A (-)-conduritol F derivative was condensed with 4-ethyl-7-hydroxy-2H-1-benzopyran-2-one and converted into (+)-4-ethyl-7-[( 1'R,2'S,3'S,4'R)-2',3',4'-trihydroxycyclohexyloxy]-2H-1benzopyran-2-one ((+)-2) Enantiomer (-)-2 was obtained from a (+)-conduritol ...
The three peroxisome proliferator-activated receptors (PPARs), PPAR alpha, delta and gamma, form a subfamily of the nuclear hormone receptor gene family. PPAR alpha has been shown to bind and be activated by leukotriene B4 and fibrates, whereas prostagland ...
