Concept
Métastase (médecine)
Publications associées (222)
Unveiling breast cancer metastasis through an advanced X-ray imaging approach
Breast cancer is a significant global health burden, causing a substantial number of deaths. Systemic metastatic tumour cell dissemination is a major cause of poor outcomes. Understanding the mechanisms underlying metastasis is crucial for effective interv ...
Berlin2024Milestones in tumor vascularization and its therapeutic targeting
Michele De Palma, Douglas Hanahan
Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising thera ...
Nature Portfolio2024Metabolic dependencies of metastasis-initiating cells in breast cancer
Metastasis is the process by which cancer cells from the primary tumor travel through the blood stream to generate a secondary tumor site in a distant organ. Although very few cells are able to make this journey, the resulting effects are dire since most c ...
EPFL2023Tumor dormancy: EMT beyond invasion and metastasis
Cathrin Brisken, Hazel Margaret Quinn, Patrik Aouad
More than two-thirds of cancer-related deaths are attributable to metastases. In some tumor types metastasis can occur up to 20 years after diagnosis and successful treatment of the primary tumor, a phenomenon termed late recurrence. Metastases arise from ...
WILEY2023Metabolic dependencies of metastasis-initiating cells in female breast cancer
Albert Santamaria Martinez, Pierre Vincent Dessen, Angela Madurga Alonso, Candice Megan T Young, Laurent Nam Ky Beziaud
Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...
Berlin2023Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis
Michele De Palma, Nahal Mansouri
Aims: Understanding the correlations between underlying medical and personal characteristics of a patient with cancer and the risk of lung metastasis may improve clinical management and outcomes. We used machine learning methodologies to predict the risk o ...
2023Regulation and function of a hemicleaved Activin-A processing intermediate in melanoma
Activin-A is a Transforming Growth Factor-B (TGFB)-related cytokine that regulates various biological processes including cell proliferation and differentiation through autocrine, paracrine or endocrine signaling. Activin-A expression is upregulated in mul ...
EPFL2023Optimized Modeling of Metastatic Triple-Negative Invasive Lobular Breast Carcinoma
Cathrin Brisken, Georgios Sflomos, Laura Battista
Simple Summary Invasive lobular carcinoma (ILC) is the second most common histologic subtype of breast cancer and is often detected at an advanced stage. Up to 30% of ILC cases relapse and present a challenge for treatment. Unfortunately, there are few mod ...
MDPI2023Direct In Vivo Activation of T Cells with Nanosized Immunofilaments Inhibits Tumor Growth and Metastasis
Bart Deplancke, Guido Van Mierlo, Jorieke Weiden
Adoptive T cell therapyhas successfully been implementedfor thetreatment of cancer. Nevertheless, ex vivo expansion of T cells byartificial antigen-presenting cells (aAPCs) remains cumbersome andcan compromise T cell functionality, thereby limiting their t ...
AMER CHEMICAL SOC2023