Concept

Intron

Publications associées (51)

A transcript perspective on evolution

Alternative splicing is now recognized as a major mechanism for transcriptome and proteome diversity in higher eukaryotes, yet its evolution is poorly understood. Most studies focus on the evolution of exons and introns at the gene level, while only few co ...

Ieee Computer Soc2013

Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

Istvan Bartha

Background: Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential ro ...

Biomed Central Ltd2013

MiR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

Mario Leonardo Squadrito, Ferdinando Pucci

Expression of the mannose receptor (MRC1/CD206) identifies macrophage subtypes, such as alternatively activated macrophages (AAMs) and M2-polarized tumor-associated macrophages (TAMs), which are endowed with tissue-remodeling, proangiogenic, and protumoral ...

Cell Press2012

Spinal muscular atrophy pathogenic mutations impair the axonogenic properties of axonal-survival of motor neuron

Veronica Setola

The axonal survival of motor neuron (a-SMN) protein is a truncated isoform of SMN1, the spinal muscular atrophy (SMA) disease gene. a-SMN is selectively localized in axons and endowed with remarkable axonogenic properties. At present, the role of a-SMN in ...

Wiley-Blackwell2012

Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2

Beat Fierz

It is well established that chromatin is a destination for signal transduction, affecting many DNA-templated processes. Histone proteins in particular are extensively post-translationally modified. We are interested in how the complex repertoire of histone ...

2012

Control of endogenous gene expression timing by introns

Andrew Charles Oates

2011

Inferring transcript phylogenies

Bernard Moret, Yann Christinat

Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals-some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite m ...

IEEE Press2011

Inferring transcript phylogenies

Bernard Moret, Yann Christinat

Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals - some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite ...

IEEE Press2011

A regulatory ‘landscape effect’ over the Hoxd cluster

Denis Duboule

Faithful expression of Hox genes in both time and space is essential for proper patterning of the primary body axis. Transgenic approaches in vertebrates have suggested that this collinear activation process is regulated in a largely gene cluster-autonomou ...

Elsevier2011

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Bart Deplancke, Jacques Rougemont, Fabrice David, Andreas Massouras, Alexandre Gattiker, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

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