Concept
Brugia malayi
Publications associées (11)
Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers
Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson
Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels
Marco Pisano, Melody Swartz, Witold Waldemar Kilarski
Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors ...
Springer2019Microfluidic high-content phenotypic screening on a Caenorhabditis elegans model
Caenorhabditis elegans is a performant model system for studying human biological processes and diseases and for pre-clinical phenotyping screenings of compounds. Microfluidics has been instrumental in enabling C. elegans-based drug assays, facilitating th ...
EPFL2018Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis
Melody Swartz, Patrycja Nowak-Sliwinska, Witold Waldemar Kilarski, Renata Katarzyna Mezyk-Kopec
Lymphatic vessels transport fluid, antigens, and immune cells to the lymph nodes to orchestrate adaptive immunity and maintain peripheral tolerance. Lymphangiogenesis has been associated with inflammation, cancer metastasis, autoimmunity, tolerance and tra ...
Springer2014Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...
American Society for Clinical Investigation2013Advances in helminth immunology: optimism for future vaccine design?
Intestinal helminths infect approximately 2 billion people worldwide. Worm burdens correlate with disease morbidity and children generally harbor the largest numbers. The majority of intestinal helminths do not replicate within their host, and worm burdens ...
2011A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications
Melody Swartz, Jan Overney, James Brandon Dixon, Adrian Chung-Kai Shieh, Carmen Bonvin
Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current models that incorporate interstitial flow and that are suitable fo ...
Wiley-Blackwell2010Molecular and mechanical regulators of lymphatic biology
Lymphatic vessels exist in nearly all tissues, yet, despite their omnipresence, there remains a large knowledge gap between the described fundamental roles of lymphatic capillaries and our understanding of their functional biology, adaptive ability, and pa ...
EPFL2008