Concept

Adrénaline

Publications associées (33)

SIRT1 enhances glucose tolerance by potentiating brown adipose tissue function

Carlos Canto Alvarez, Joanna Ratajczak, Pablo Jose Fernandez Marcos

Objective: SIRT1 has been proposed to be a key signaling node linking changes in energy metabolism to transcriptional adaptations. Although SIRT1 overexpression is protective against diverse metabolic complications, especially in response to high-fat diets ...

Elsevier Science Bv2015

An Ex vivo Model to Study Hormone Action in the Human Breast

Cathrin Brisken, Georgios Sflomos

The study of hormone action in the human breast has been hampered by lack of adequate model systems. Upon in vitro culture, primary mammary epithelial cells tend to lose hormone receptor expression. Widely used hormone receptor positive breast cancer cell ...

Journal of Visualized Experiments2015

Enzyme and Acid Deconjugation of Plasma Sulfated Metanephrines

Sandrine Gerber

Background: Total (i.e. free + sulfated) metanephrines in plasma is a biomarker for the diagnosis of pheochromocytoma/paraganglioma. Sulfated metanephrines must be completely deconjugated by perchloric acid hydrolysis or sulfatase treatment prior to analyt ...

Elsevier2014

Influence of atrial substrate on local capture induced by rapid pacing of atrial fibrillation

Jean-Marc Vesin, Vincent Jacquemet, Alexandru Rusu

Preliminary studies showed that the septum area was the only location allowing local capture of both the atria during rapid pacing of atrial fibrillation (AF) from a single site. The present model-based study investigated the influence of atrial substrate ...

Oxford University Press2014

Peripubertal stress-induced behavioral changes are associated with altered expression of genes involved in excitation and inhibition in the amygdala

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Orbicia Riccio Wicht

Early-life stress is a critical risk factor for developing psychopathological alterations later in life. This early adverse environment has been modeled in rats by exposure to stress during the peripubertal period-that is, corresponding to childhood and pu ...

Nature Publishing Group2014

Improving the Electrochemical Activity of LiMnPO4 Via Mn-Site Substitution

Michael Graetzel, Mingkui Wang, Nam Hee Kwon

HPL SA report the modification of the electrochemical performance of lithium manganese phosphate (LiMnPO4) via Mn-site bivalent substitution. Manganese (10%) is substituted with iron, nickel, magnesium, or zinc. These substituents are shown via an X-ray to ...

2010

Selective Glutamate Biosensor Arrays Integrated on Silicon Microprobes for In vivo Brain Recordings

Nico de Rooij, Peter Van der Wal, Olivier Frey

Real-time monitoring of glutamate, being the primary excitatory neurotransmitter, is of utmost importance for understanding the functioning of the central nervous system. Since expected concentrations and its variation in the brain are in the range of 0.5 ...

2010

Mechanistic studies on the tyrosinase-catalyzed formation of the anachelin chromophore

Karl Gademann

The complex secondary metabolite anachelin, isolated from the freshwater cyanobacterium Anabaena cylindrica, is believed to act as siderophore, facilitating iron uptake. Its structure is characterized by a fascinating blend of polyketide, peptide, and alka ...

2005

Synthesis and Evaluation of the Bis-Nor-Anachelin Chromophore as Potential Cyanobacterial Ligand

Karl Gademann

The cyanobacterial metabolite anachelin, postulated to serve as a biological ligand to Fe (siderophore), is composed of a fascinating blend of polyketide, peptide, and alkaloid building blocks. In particular, the latter consists of a N,N-dimethyltetrahydro ...

2005

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

Patrick Aebischer, Bernard Schneider, Manuel Bauer, Christophe Lo Bianco

Parkinson's disease (PD) is characterized by a progressive loss of midbrain dopamine neurons and the presence of cytoplasmic inclusions called Lewy bodies. Mutations in several genes including alpha-synuclein and parkin have been linked to familial PD. The ...

2004

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