Concept

Metabolic engineering

Publications associées (95)

Systematic characterization of flux and network thermodynamic states for identification of metabolic engineering targets

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh

In order to identify targets for metabolic engineering interventions or understand the physiology of the cell, the first and foremost prerequisite is the knowledge or a hypothesis about the intracellular network state(s). However, even with the advanced me ...

2012

A novel approach to find the missing links in genome-scale metabolic models: The BridgeIt mrthod

Vassily Hatzimanikatis, Keng Cher Soh, Marianne Seijo

Genome-scale metabolic reconstructions (GSMRs) are valuable resources in the analysis and understanding of cellular metabolism. They are based on genome sequence and annotation, and they are to develop bottom-up mathematical models of metabolic networks. T ...

2012

From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks

Vassily Hatzimanikatis, Ljubisa Miskovic, Keng Cher Soh

Many important problems in cell biology arise from the dense nonlinear interactions between functional modules. The importance of mathematical modelling and computer simulation in understanding cellular processes is now indisputable and widely appreciated. ...

Wiley-Blackwell2011

Metabolic pathway and distribution of superparamagnetic iron oxide nanoparticles: in vivo study

Heinrich Hofmann

Background: Experimental tissue fusion benefits from the selective heating of superparamagnetic iron oxide nanoparticles (SPIONs) under high frequency irradiation. However, the metabolic pathways of SPIONs for tissue fusion remain unknown. Hence, the goal ...

2011

Production of a thermostable fumarase in Saccharomyces cerevisiae for the bioconversion of fumarate to L-malate

Coralie Signorell

The gene encoding fumarase (fum) from Thermus thermophilus was expressed in yeast Saccharomyces cerevisiae. The recombinant cells were heated at 70°C to inactivate indigenous enzymes and used for the bioconversion of fumaric acid to L-malic acid. By heatin ...

2011

DREAMS of metabolism

Vassily Hatzimanikatis, Keng Cher Soh

Metabolic networks have been studied for decades, and sophisticated computational frameworks are needed to augment experimental approaches to harness these complex networks. BNICE (Biochemical Network Integrated Computational Explorer), a computational app ...

Elsevier2010

Computational Analysis of Xylose-Utilizing Saccharomyces cerevisiae

Vassily Hatzimanikatis, Ljubisa Miskovic

Xylose fermentation from lignocellulosic material using recombinant yeast cells is a promising resource for efficient ethanol production as a future sustainable energy supply. Experimental approaches emphasize the engineering of xylose-utilizing recombinan ...

2010

Synthetic Studies on Daphmanidin C and Maytenone Based on Biosynthetic Considerations and Natural Product Hybrids as Tools for Quorum Sensing

Adrien Keith Lawrence

The isolation and characterisation of natural products remains a challenge in chemistry owing to nature's magnificent diversity. Natural products or natural product derivatives have always been used in traditional medicine to treat a variety of diseases. T ...

EPFL2010

Carbon Nanotubes-Based Electrochemical Sensing for Cell Culture Monitoring

Giovanni De Micheli, Sandro Carrara, Cristina Boero, Giovanna Del Vecchio

Monitoring of metabolic compounds, such as glucose and lactate, is extensively reported in literature, especially for clinical purposes. Instead, the application of such technologies for monitoring metabolites in cell cultures has not been explored. From o ...

2010

Quantification of uncertainty in metabolic networks through the sampling of kinetic data space

Vassily Hatzimanikatis, Ljubisa Miskovic

Study of a metabolic network with respect to the sensitivity of the metabolite concentrations and the metabolic fluxes to genetic, biochemical, and environmental variations requires knowledge of the kinetic properties of the enzymes in the network. Experim ...

2009

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