Concept

Microvillosité

Publications associées (14)

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

In this work we introduce a theoretical and computational modeling framework for the contractile response of single cells triggered by external mechanical stimuli. The structural response due to the formation and dissociation of stress fibers is modeled fo ...

2018

A model for cellular mechanotransduction and contractility at finite strain

William Curtin, Mahmut Selman Sakar, Nikolaos Bouklas

2018

Structure and Analysis of R1 and R2 Pyocin Receptor-Binding Fibers

Petr Leiman, Sergii Buth

The R-type pyocins are high-molecular weight bacteriocins produced by some strains of Pseudomonas aeruginosa to specifically kill other strains of the same species. Structurally, the R-type pyocins are similar to simple contractile tails, such as those of ...

2018

Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147

Membrane transporters influence biological functions in the ocular lens. Here, we investigate the monocarboxylate transporter 12 (MCT12), also called creatine transporter 2 (CRT2), which is found in the ocular lens and is involved in cataract. As the age-r ...

Oxford Univ Press2017

Thioester-containing proteins regulate the Toll pathway and play a role in Drosophila defence against microbial pathogens and parasitoid wasps

Bruno Lemaitre, Samuel Rommelaere, Anna Dostalova

Background: Members of the thioester-containing protein (TEP) family contribute to host defence in both insects and mammals. However, their role in the immune response of Drosophila is elusive. In this study, we address the role of TEPs in Drosophila immun ...

2017

Ultra-soft cantilevers and 3-D micro-patterned substrates for contractile bundle tension measurement in living cells

Jean-Jacques Meister, Niccolo Piacentini, Chiara Gabella, Benoît Vianay

Actin-myosin microfilament bundles or stress-fibers are the principal tension-generating structures in the cell. Their mechanical properties are critical for cell shape, motion, and interaction with other cells and extracellular matrix, but were so far dif ...

Royal Society of Chemistry2014

Analysis of damping rate measurements of toroidal Alfven eigenmodes as a function of n: part I

Ambrogio Fasoli, Duccio Testa, Theodoros Panis

Complementing the database approach that has been presented in part I, this paper probes into individual plasma discharges and investigates the damping rate variations that are driven by the evolving plasma configurations. In addition to confirming the sta ...

2012

Arterial biomechanics after destruction of cytoskeleton by Cytochalasin D

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci, Tyler Nerton Thacher

Vascular smooth muscle is a major structural element of the arterial wall. We examined the effects of cytoskeleton destruction, after administration of Cytochalasin D, on the biomechanical properties of porcine common carotids. Compared to untreated, maxim ...

2009

Differential requirement for beta-catenin in epithelial and fiber cells during lens development

Recent studies implicate Wnt/beta-catenin signaling in lens differentiation (Stump, R. J., et al., 2003. A role for Wnt/beta-catenin signaling in lens epithelial differentiation. Dev Biol;259:48-61). Beta-catenin is a component of adherens junctions and fu ...

2008

Vascular physiology

Sylvain Roy

This thesis aims at better understanding the role played by vascular smooth muscle cells (VSM) in the biomechanics of the arterial wall. Current models assume that under maximal vasodilation VSM carry no load, or the so-called "active stress" is zero. Biom ...

EPFL2008

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