Concept
Embryologie
Publications associées (33)
Generation of a Gal4-dependent gene recombination and illuminating mouse
Cell labeling technologies, including the Cre/loxP system, are powerful tools in developmental biology. Although the conventional Cre/loxP system has been extensively used to label the expression of specific genes, it is less frequently used for labeling p ...
INT PRESS EDITING CENTRE INC2022Post-translational regulation of neuronal differentiation
Glycosphingolipids (GSLs) are amphipathic lipid moieties that make up only 3% of the total lipid content of the cell and are almost exclusively expressed at the Plasma Membrane(PM). They are key drivers of signalling hotspots known as âlipid-raftsâ as ...
EPFL2021Inter-embryo gene expression variability recapitulates the hourglass pattern of evo-devo
Bart Deplancke, Vincent Roland Julien Gardeux, Michael Vincent Frochaux
Background The evolution of embryological development has long been characterized by deep conservation. In animal development, the phylotypic stage in mid-embryogenesis is more conserved than either early or late stages among species within the same phylum ...
2020An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages
Christopher Chase Bolt, Soumya Negi
The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynami ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019The Detection of Early Epigenetic Inheritance of Mitochondrial Stress in C. Elegans with a Microfluidic Phenotyping Platform
Johan Auwerx, Martinus Gijs, Matteo Cornaglia, Hüseyin Baris Atakan
Fluctuations and deterioration in environmental conditions potentially have a phenotypic impact that extends over generations. Transgenerational epigenetics is the defined term for such intergenerational transient inheritance without an alteration in the D ...
2019Coordinated Hoxd genes expression during embryogenesis is dependent on a strict disposition of genes and polarized regulators within the HoxD cluster
HOX transcription factors determine the identity of body regions along the rostro-caudal axis during bilaterian embryogenesis. In vertebrates Hox genes distinctively lie organized in dense clusters, each typically composed of a dozen paralogous transcripti ...
EPFL2018Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation
TAF4 (TATA-binding protein-associated factor 4) and its paralogue TAF4b are components of the TFIID core module. We inactivated the murine Taf4a gene to address Taf4 function during embryogenesis. Here we show that Taf4a(-/-) embryos survive until E9.5 whe ...
Nature Publishing Group2016Distinct mechanisms eliminate mother and daughter centrioles in meiosis of starfish oocytes
Centriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live ...
2016Transposable Elements, Polydactyl Proteins, and the Genesis of Human-Specific Transcription Networks
Transposable elements (TEs) may account for up to two-thirds of the human genome, and as genomic threats they are subjected to epigenetic control mechanisms engaged from the earliest stages of embryonic development. We previously determined that an importa ...
2016Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract
Background-Congenital heart disease is the most common type of birth defect, affecting approximate to 2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bi ...
Wiley-Blackwell2016