Concept

Système nerveux autonome

Publications associées (377)

Implantable neurological probe for performing physiological measurement of patient, has microelectrode element that is arranged along the protrusion extended away from surface of supportive backing layer

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

2011

Laser-Doppler flowmetry at large interoptode spacing in human tibia diaphysis: Monte Carlo simulations and preliminary experimental results

Dimitri Nestor Alice Van De Ville

Laser-Doppler flowmetry (LDF) is an outstanding tool to monitor blood flow in a continuous and non-invasive way. In this work, we study LDF at large interoptode spacing applied to a human bone model (i.e. tibia diaphysis). To that aim, we first performed a ...

Institute of Physics2011

Mercury is a direct and potent γ-secretase inhibitor affecting Notch processing and development in Drosophila

Bruno Lemaitre, Patrick Fraering, Mitko Dimitrov, Takayuki Kuraishi, Isabelle Chang

Prenatal exposure to mercury causes neurodevelopmental disorders and neurological pathologies in infants, such as microcephaly and mental retardation. Despite critical importance, the molecular interactions leading to mercury toxicity are yet to be elucida ...

2011

Epigenetic regulation of gene expression in physiological and pathological brain processes

Johannes Gräff

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are an integral part of a multitude of brain functions that range from the development of the nervous system over basic neuronal functions to higher order cognitive process ...

2011

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hélène Danielle Perreten Lambert

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011

Controlling selective stimulations below a spinal cord hemisection using brain recordings with a neural interface system approach

Silvestro Micera

In this work we address the use of realtime cortical recordings for the generation of coherent, reliable and robust motor activity in spinal-lesioned animals through selective intraspinal microstimulation (ISMS). The spinal cord of adult rats was hemisecti ...

2011

Neuro-fuzzy decoding of sensory information from ensembles of simultaneously recorded dorsal root ganglion neurons for functional electrical stimulation applications

Silvestro Micera, Jacopo Rigosa

Functional electrical stimulation (FES) is used to improve motor function after injury to the central nervous system. Some FES systems use artificial sensors to switch between finite control states. To optimize FES control of the complex behavior of the mu ...

2011

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

Bernard Schneider, Jean-Charles Bensadoun

Several diseases and injuries of the central nervous system could potentially be treated by delivery of an enzyme, which might most effectively be achieved by gene therapy. In particular, the bacterial enzyme chondroitinase ABC is beneficial in animal mode ...

Elsevier2011

Identification of Signaling Mechanisms Determining the Development of Large Excitatory Synapses in the Lower Auditory System

Le Xiao

In the brainstem auditory circuit of mammals and birds, excitatory synapses with extraordinarily large size have evolved, which ensure fast membrane potential signaling mediated by large, multiquantal excitatory postsynaptic currents (EPSCs). The so-called ...

EPFL2011

Morphological development of thick-tufted layer v pyramidal cells in the rat somatosensory cortex

Henry Markram, Yun Wang, Sandrine Romand

The thick-tufted layer V pyramidal (TTL5) neuron is a key neuron providing output from the neocortex. Although it has been extensively studied, principles governing its dendritic and axonal arborization during development are still not fully quantified. Us ...

2011

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