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Publications associées (136)

Chemosensors Based on Metal-Dye Complexes for Bioanalytes

Multicomponent chemosensors were prepared by mixing the rhodium(III) complex [(η5-C5Me5)RhCl 2]2, nickel(II) chloride and/or copper(II) chloride with commercially available dyes in buffered aqueous solution. The sensors were used to detect various biomolec ...

EPFL2010

Enol Phosphinates and Phosphonates: Practical Electrophiles for Cross-Coupling Strategies

Tom Woods

Enol phosphinates and phosphonates can be readily prepared from simple lactams in high yields and are both stable and storable. Both these substrates can be employed successfully in homogeneous Suzuki-Miyaura and Stille cross-couplings protocols. Additiona ...

2009

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Paolo Silacci, Tyler Nerton Thacher, Veronica Gambillara

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Synthetic Studies on (-)-Lemonomycin: An Efficient Asymmetric Synthesis of Lemonomycinone Amide

Jieping Zhu

Asym. synthesis of lemonomycinone amide was accomplished from readily accessible starting materials. Enantioselective alkylation of N-(diphenylmethylene)glycine tert-Bu ester by 5-tert-butyldimethylsilyloxy-2,4-dimethoxy-3-methylbenzyl bromide in the prese ...

2009

Invertible Enantioselectivity in 6'-Deoxy-6'-acylamino-beta -isocupreidine-Catalyzed Asymmetric Aza-Morita-Baylis-Hillman Reaction: Key Role of Achiral Additive

Jieping Zhu

The beta -isocupreidine (beta -ICD) or beta -ICD-amide (I)-catalyzed aza-Morita-Baylis-Hillman reaction between N-sulfonylimines and alkyl vinyl ketones produced the (R)-enriched adducts, e.g. II. By adding a catalytic amt. of beta -naphthol, the enantiose ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall and on smooth muscle function

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Tyler Nerton Thacher

Cyclic circumferential stretch and shear stress act in concert and yet are capable of independently mediating arterial smooth muscle function, modulating the production of superoxide and stimulating arterial remodeling. ...

Oxford University Press2009

Transferring the Concept of Multinuclearity to Ruthenium Complexes for Improvement of Anticancer Activity

Kay Severin, Alexey Nazarov, Michael Groessl

Multinuclear platinum anticancer complexes are a proven option to overcome resistance of established anticancer compounds. Transferring this concept to ruthenium complexes led to the synthesis of dinuclear Ru(II)-arene compounds containing a bis(pyridinone ...

2009

Hafnium Trifluoromethanesulfonate (Hafnium Triflate) as a Highly Efficient Catalyst for Chemoselective Thioacetalization and Transthioacetalization of Carbonyl Compounds

Jieping Zhu

A range of carbonyl compds. including aliph. and arom. aldehydes and ketones were converted to the corresponding thioacetals in high yields in the presence of a catalytic amt. of hafnium trifluoromethanesulfonate (0.1 mol%, room temp.). The mild conditions ...

2008

Synthesis and L-fucosidase inhibitory potency of a cyclic sugar imine and its pyrrolidine analogue

Pierre Vogel, Claudia Bello

The synthesis of a fully deprotected ketimine-type iminosugar is reported, starting from commercial D-mannose diacetonide. An appropriate solvent system was critical for the success of the key tandem addition/cyclization reaction. Reduction of the imine wa ...

2008

Synthesis of alpha -keto amides by a molecular-sieves-promoted formal oxidative coupling of aliphatic aldehydes with isocyanides

Jieping Zhu

The reaction of an aldehyde, an isocyanide, N-methylhydroxylamine, and acetic acid in the presence of 4-.ANG. mol. sieves afforded alpha -keto amides in moderate to good yields. In contrast, 3-.ANG. mol. sieves did not promote the desired multicomponent re ...

2008

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