Concept

Desquamation

Publications associées (23)

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

Freddy Radtke, Ute Koch, Matteo Di Piazza

BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...

Public Library of Science2010

On the replication of adeno-associated virus in the presence or absence of viral helper functions

Anika Ekrut

Adeno-associated virus (AAV) is a small non-enveloped virus and as a member of the parvovirus family, it contains a single stranded DNA genome. AAV's life cycle in vitro is strongly dependent not only on cellular factors but also on helper functions provid ...

EPFL2009

Understanding engraftment of cultured epidermal stem cells

Nicolas Grasset

The epidermis and its appendages protect our body from environmental hazards. Cells generated in the basal layer continuously replace the terminally differentiated keratinocytes that are shed off the epidermal surface. Long-term renewal depends on specific ...

EPFL2008

Multiple roles of Notch signaling in the regulation of epidermal development

Freddy Radtke

Recent studies have shown that Notch signaling plays an important role in epidermal development, but the underlying molecular mechanisms remain unclear. Here, by integrating loss- and gain-of-function studies of Notch receptors and Hes1, we describe molecu ...

2008

Fine modulation of stem cell niche through mTOR pathway : Effects of physical and molecular parameters regulating mTOR pathway on keratinocyte stem cells

Johannes Alexander Mosig

Epidermis is the outermost layer of the skin and is in direct contact with the external environment, requiring keratinocyte stem cells to adapt constantly. Recently, our laboratory has put forward the role of mTOR in temperature-mediated keratinocyte stem ...

2008

Photocatalytic discoloration of Methyl Orange on innovative parylene–TiO2 flexible thin films under simulated sunlight

Albert Renken, Lioubov Kiwi, Juan Kiwi, Danièle Laub

Parylene films loaded with TiO2 are reported as hotocatalysts in azo dye discoloration processes. The TiO2 loading of the parylene film was 0.32% (w/w) and the amount of TiO2 on the film was about two orders of magnitude below the TiO2 added in suspension ...

2008

Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes

Jean-Jacques Meister, Boris Hinz

Myofibroblasts are specialized fibroblasts that contribute to wound healing by producing extracellular matrix and by contracting the granulation tissue. They appear in a phase of wound healing when the dermis strongly interacts with activated epidermal ker ...

Schattauer2004

Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero

Johan Auwerx, Kristina Schoonjans

The protective function of the skin is mediated by the stratum corneum, the outermost layer of the skin, which is the end-product of epidermal differentiation. Previously, we showed that fetal rat skin explants complete the late-stage milestones of epiderm ...

2002

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

To examine the consequences of repressing beta-catenin/Lef1 signalling in mouse epidermis, we expressed a DeltaNLef1 transgene, which lacks the beta-catenin binding site, under the control of the keratin 14 promoter. No skin abnormalities were detected bef ...

2002

Systematic studies of (magneto)transport, structural and electronic properties of ultra-thin films of high-T-c cuprates and related layered oxides

Giorgio Margaritondo, Davor Pavuna, Dominique Cloëtta, Mike Abrecht

Properties of ultra-thin films are different from their single crystal counterparts due to the presence of (substrate induced) strain, different degree and type of (growth induced) disorder and different average doping (distribution of oxygen vacancies, fo ...

2002

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search