Publications associées à Antigen processing

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Jeffrey Alan Hubbell, Mikaël Martino, Alexandre de Titta, Laura Jeanbart, Ziad Julier

Fibronectin (FN) is an extracellular matrix (ECM) protein including numerous fibronectin type III (FNIII) repeats with different functions. The alternatively spliced FN variant containing the extra domain A (FNIII EDA), located between FNIII 11 and FNIII 1 ...

Nature Publishing Group2015

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Stephane Kontos, Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with apoptotic debris are known to be processed tolerogenically ...

Nature Publishing Group2015

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Melody Swartz

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the tumor microenvironment and in the tumor-draining lymph node. The mechanism unde ...

Amer Assoc Cancer Research2014

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Mario Michael Zaiss, Zhen Chen

Bone resorption is seminal for the physiological remodeling of bone during life. However, this process needs to be strictly controlled; excessive bone resorption results in pathologic bone loss, osteoporosis, and fracture. We describe a control mechanism o ...

Amer Assoc Advancement Science2014

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

Yury Tsybin, Luca Fornelli, Daniel Ayoub

The rapid growth of approved biotherapeutics, e.g., monoclonal antibodies or immunoglobulins G (IgGs), demands improved techniques for their quality control. Traditionally, proteolysis-based bottom-up mass spectrometry (MS) has been employed. However, the ...

Amer Chemical Soc2014

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Stephane Kontos, Jeffrey Alan Hubbell, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength

Freddy Radtke, Ute Koch, Tao Wang

In humans, high Notch activation promotes gamma delta T cell development, whereas lower levels promote alpha beta-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor-ligand ...

Rockefeller University Press2013

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Ziad Julier

In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after int ...

Natl Acad Sciences2013

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Antigen processing

Modes of antigen presentation by lymph node stromal cells and their immunological implications

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

Graph Chatbot

Chattez avec Graph Search

Modes of antigen presentation by lymph node stromal cells and their immunological implications

The TLR4 Agonist Fibronectin Extra Domain A is Cryptic, Exposed by Elastase-2; use in a fibrin matrix cancer vaccine

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose

Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Middle-down analysis of monoclonal antibodies with electron transfer dissociation Orbitrap FTMS

T Cell Costimulation Molecules CD80/86 Inhibit Osteoclast Differentiation by Inducing the IDO/Tryptophan Pathway

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens