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Chiral alkyl amines are omnipresent as bioactive molecules and synthetic intermediates. The catalytic and enantioselective synthesis of alkyl amines from readily accessible precursors is challenging. Here we develop a nickel-catalyzed hydroalkylation metho ...
In this section, the synthesis of saturated N- and O-heterocycles via formal cycloaddition is presented. The main focus is on metal-catalyzed reactions involving C–C or C–X σ bond cleavage in three- or four-membered rings. After a fast presentation of pion ...
The kinetics and mechanism of the title heterogeneous halogen exchange reactions of potential atmospheric importance have been studied under molecular flow conditions in a FEP Teflon-coated Knudsen flow reactor on HX (X = Cl, Br, I) - doped ice condensed f ...
Transfer of chirality during the build-up of molecules has been applied innumerable times in organic chemistry since the end of the 19th century, when it was introduced in the so-called asymmetric synthesis by E. Fischer. Although analogous reactions were ...
During deamination, γ-amino acids can undergo concomitant decarboxylation. Aiming at studying the course of the involved reaction, the following γ-amino acids were synthesized and characterized: (–)-3c-amino-1,2,2-trimethylcyclopentane-1r-carboxylic acid ( ...
A copper-catalyzed alkylation of allylic alcohols by alkyl nitriles with concomitant 1,2-aryl migration was developed. Formation of the alkyl nitrile radical was followed by its intermolecular addition to alkenes and the migration of a vicinal aryl group w ...
The C-13-{H-1} NMR spectra of two monofluorinated nematic liquid crystals, I35 and I52, have been obtained and analysed to yield sets of dipolar couplings, D-iF, from each carbon in the molecule to the fluorine nucleus. The couplings involving carbons in t ...
The non-steroidal anti-inflammatory and anti-arthritic drug piroxicam (LH) reacts with arene ruthenium dichloride dimers in refluxing dichloromethane to give the complexes [(eta(6)-arene)Ru(eta(2)-N,O-L)Cl] (3: arene = C6H5Me, 4: arene = p-MeC6H4Pri, 5: ar ...
