Concept

Pool génique

Publications associées (32)

A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

Didier Trono, Jacques Rougemont, Giovanna Ambrosini, Nadine Fournier, Philipp Bucher, Adamantia Kapopoulou, Annamaria Kauzlaric, Anna Claire Groner, Sylvain Meylan

ABSTRACT: BACKGROUND: KRAB-ZFPs (Kruppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effec ...

BioMed Central2011

Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation

Stewart Cole, Jacques Rougemont, Swapna Uplekar

The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vacc ...

2011

AMP-activated protein kinase and its downstream transcriptional pathways

Johan Auwerx, Carlos Canto Alvarez

The AMP-activated protein kinase (AMPK) is a key regulator of catabolic versus anabolic processes. Its properties as an energy sensor allow it to couple the energy status of the cell to the metabolic environment. These adaptations not only take place throu ...

Birkhäuser-Verlag, Springer2010

Bottleneck genes and community structure in the cell cycle network of S-pombe

Paolo De Los Rios, Francesco Piazza, Cécile Caretta Cartozo

The identification of cell cycle-related genes is still a difficult task, even for organisms with relatively few genes such as the fission yeast. Several gene expression studies have been published on S. pombe showing similarities but also discrepancies in ...

Public Library of Science2007

Evolutionary morphogenesis for multi-cellular systems

Dario Floreano, Daniel Roggen, Diego Federici

With a gene required for each phenotypic trait, direct genetic encodings may show poor scalability to increasing phenotype length. Developmental systems may alleviate this problem by providing more efficient indirect genotype to phenotype mappings. A novel ...

2007

Regulatory constraints in the evolution of the tetrapod limb anterior-posterior polarity

Denis Duboule

The anterior to posterior (A-P) polarity of the tetrapod limb is determined by the confined expression of Sonic hedgehog (Shh) at the posterior margin of developing early limb buds, under the control of HOX proteins encoded by gene members of both the HoxA ...

2006

Mining gene sets for measuring similarities

Giovanni De Micheli, Luca Benini

In recent years, the development of high throughput devices for the massive parallel analyses of genomic data has lead to the generation of large amount of new biological evidences and has triggered the proliferation of data mining algorithms for the extra ...

2006

Viral-based modelling and correction of neurodegenerative diseases by RNA interference

Patrick Aebischer

Experimental recapitulation of recessive human genetic neurodegenerative disease in rodents can be classically addressed through genetic disruption of the related gene. Although very informative, this specific gene targeting is restricted to mice and precl ...

2006

The zebrafish KLF gene family

Andrew Charles Oates

The Krüppel-like factor (KLF) family of genes encodes transcriptional regulatory proteins that play roles in differentiation of a diverse set of cells in mammals. For instance, the founding member KLF1 (also known as EKLF) is required for normal globin pro ...

2001

Function of the Evx-2 gene in the morphogenesis of vertebrate limbs

Denis Duboule

Vertebrate gene members of the HoxD complex are essential for proper development of the appendicular skeletons. Inactivation of these genes induces severe alterations in the size and number of bony elements. Evx-2, a gene related to the Drosophila even-ski ...

1996

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