Concept

Atopie

Publications associées (8)

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Benjamin John Marsland, Alexandre de Titta, Marie Ballester, Laura Jeanbart

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Nicola Harris, Benjamin John Marsland, Ilaria Mosconi

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

The Role of LEKTI in the Fate Determination of Keratinocyte Stem Cells

Alessandro Wataru Amici

SPINK5 (serine protease inhibitor Kazal-type 5) encodes the proteinase inhibitor LEKTI (lympho-epithelial Kazal-type related inhibitor). In skin, LEKTI expression is restricted to the stratum granulosum of the epidermis and the inner root sheath of hair fo ...

EPFL2011

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin

Freddy Radtke, Ute Koch, Matteo Di Piazza

BACKGROUND: The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. ...

Public Library of Science2010

Tailoring mixed-valence CoIII/FeII complexes for their potential use as sensitizers in dye sensitized solar cells

Ulf Anders Hagfeldt

Dinuclear class II CoIII/FeII mixed-valence complexes, [LnCoIII(μ-NC)FeII(CN)3L2]m-, where Ln represents a pentadentate macrocycle and L2 a bpy ligand or 2 cyanides, have electronic properties that make them possible sensitizers in dye sensitized solar cel ...

2008

Tissue localization and frequency of antigen-specific effector CD4 T cells determines the development of allergic airway inflammation

Nicola Harris

Previous activation of effector Th2 cells is central to the development of allergic inflammatory responses. We have observed that priming of allergen-specific Th2 cells in C57BL/6 or B10.A mice with allergen delivered via the i.p. or s.c. routes results in ...

2005

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models

Johan Auwerx, Kristina Schoonjans

Activators of peroxisome proliferator activated receptor-alpha, a nuclear hormone receptor that heterodimerizes with retinoid X receptor, stimulate epidermal differentiation and inhibit proliferation. Here we determined the anti-inflammatory effects of per ...

2002

Reorganization of adsorbed films by coadsorbing species

Sylvie Roke

Coadsorption of CO and butane on a Pt(533) surface leads to a dynamical system in which both molecules influence the adsorption behavior of each other. Adsorbing butane on a Pt(533) surface with CO on atop step sites leads to tilting of CO molecules of at ...

2000

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