Concept

Évolution moléculaire

Publications associées (309)

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscape ...

Oxford Univ Press2016

Modélisation et Simulation de la ville. Le cas des villes virtuelles en 3D

Jean-François Lucas

Les outils de modélisation et de simulation en trois dimensions (3D) permettent de matérialiser la ville sous de nombreux aspects, pour répondre à des objectifs multiples (scientifique, prospectif, ludique, etc.). Cependant, au-delà de leurs différences, c ...

Manucius2016

On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity

Jeffrey David Jensen

A central focus of population genetics has been examining the contribution of selective and neutral processes in shaping patterns of intraspecies diversity. In terms of selection specifically, surveys of higher organisms have shown considerable variation i ...

Wiley-Blackwell2016

Total Synthesis of Fijiolide A via an Atropselective Paracyclophane Formation

Christoph Heinz

The natural product fijiolide A is a secondary metabolite isolated from a marine-derived actinomycete of the genus Nocardiopsis. It displays inhibitory activity against TNF-Î±-induced activation of NFÎºB, an important transcription factor and a potential t ...

EPFL2016

X-Point Effect on Plasma Blob Dynamics

Ambrogio Fasoli, Ivo Furno, Paolo Ricci, Christian Gabriel Theiler, Fabio Avino

Plasma blob dynamics on the high-field side in the proximity of a magnetic field null (X point) is investigated in TORPEX. A significant acceleration of the blobs towards the X point is observed. Close to the X point the blobs break apart. The E x B drifts ...

American Physical Society2016

NEMo: An Evolutionary Model with Modularity for PPI Networks

Bernard Moret, Xiuwei Zhang, Min Ye, Qijia Jiang, Gabriela Clara Racz

Modelling the evolution of biological networks is a major challenge. Biological networks are usually represented as graphs; evolutionary events include addition and removal of vertices and edges, but also duplication of vertices and their associated edges. ...

Springer Int Publishing Ag2016

SNP2TFBS - a database of regulatory SNPs affecting predicted transcription factor binding site affinity

Giovanna Ambrosini, Philipp Bucher, Sunil Kumar

SNP2TFBS is a computational resource intended to support researchers investigating the molecular mechanisms underlying regulatory variation in the human genome. The database essentially consists of a collection of text files providing specific annotations ...

Oxford University Press2016

An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Sebastian Matuszewski, Hyunjin Shim

The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus to develop resistance against current antivirals and vaccines. He ...

Wiley-Blackwell2016

Modeling Flow Pattern and Evolution of Meandering Channels with a Nonlinear Model

Koen Blanckaert

Meander dynamics has been the focus of river engineering for decades; however, it remains a challenge for researchers to precisely replicate natural evolution processes of meandering channels with numerical models due to the high nonlinearity of the govern ...

Mdpi Ag2016

XacFhaB adhesin, an important Xanthomonas citri ssp citri virulence factor, is recognized as a pathogen-associated molecular pattern

Luciano Andres Abriata

Adhesion to host tissue is one of the key steps of the bacterial pathogenic process. Xanthomonas citri ssp. citri possesses a non-fimbrial adhesin protein, XacFhaB, required for bacterial attachment, which we have previously demonstrated to be an important ...

Wiley-Blackwell2016

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