Concept

Synthon

Publications associées (8)

Divergent Asymmetric Total Synthesis of (−)‐Voacafricines A and B

Qian Wang, Jieping Zhu, Rémi Julien Sylvain Andres

A divergent asymmetric total synthesis of voacafricines A and B, hexacyclic monoterpene indole alkaloids, has been accomplished featuring the following key steps: a)a catalyst-controlled asymmetric Pictet– Spengler reaction of 6-methoxytryptamine with a ch ...

2023

Aliphatic Carboxylic Acids as Coupling Partners in Carbon-Heteroatom Bond-Forming Reactions

Runze Mao

Carboxylic acids are one of the most suitable starting materials for synthesis. They are readily available and therefore inexpensive, stable and non-toxic. Many carboxylic acids can be obtained directly from natural resources, thus avoiding the extraction ...

EPFL2020

Dearomatization of electron poor six-membered N-heterocycles through [3+2] annulation with aminocyclopropanes

Jérôme Waser, Johannes Preindl, Shyamal Chakrabarty

Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines and isoquinolines reacted with donor- ...

2017

Soft Approaches to CO2 Activation

Paul Joseph Dyson, Felix Daniel Bobbink, Aswin Gopakumar, Shoubhik Das

The utilization of CO2 as a C1 synthon is becoming increasingly important as a feedstock derived from carbon capture and storage technologies. Herein, we describe some of our recent research on carbon dioxide valorization, notably, using organocatalysts to ...

Swiss Chemical Soc2015

Pd(0)-Catalyzed Alkene Oxy- and Aminoalkynylation with Aliphatic Bromoacetylenes

Jérôme Waser, Stefano Nicolai, Raha Sedigh-Zadeh

Tetrahydrofurans and pyrrolidines are among the most important heterocycles found in bioactive compounds. Cyclization-functionalization domino reactions of alcohols or amines onto olefins,constitute one of the most efficient methods to access them. In this ...

American Chemical Society2013

New Acetylene Chemistry

Davinia Fernández González

This thesis is divided in seven main chapters including an introduction about the state of the art in the field, four main chapters describing the main part of the work, a short insight on the implications of the presented results for other research projec ...

EPFL2011

Synthèses, structures et applications catalytiques de nouveaux complexes polynucléaires

Sébastien Gauthier

Various methods for the synthesis of bimetallic complexes, in which two different metal fragments which are connected by two or three halogeno bridges, are reported. The reactions are usually fast and give rise to structurally defined products in quantitat ...

EPFL2006

A fluoroisoprenylation sequence employing 2-fluoroalkenal derived azomethines as key intermediates: a stereocontrolled synthesis of 2-fluorogeraniol and 2-fluorofarnesol

Azomethines (Schiff's bases) derived from a,b-unsatd. a-fluoroaldehydes can be deprotonated with lithium diisopropylamide. The resulting "anions" or, correctly, 3-fluoro-1-azapentadienyl lithium compds. are conformationally mobile. While eight different ...

1994

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