Concept

Hypolipémiant

Publications associées (52)

Cytotoxic Effects of Combination of Oxidosqualene Cyclase Inhibitors with Atorvastatin in Human Cancer Cells

Ten oxidosqualene c-yclase inhibitors with high efficacy as cholesterol-lowering agents and of different chemical structure classes were evaluated as potential anticancer agents against human cancer cells from various tissue origins and nontumoral human-br ...

2012

Consequences of Exchanging Carbohydrates for Proteins in the Cholesterol Metabolism of Mice Fed a High-fat Diet

Sylviane Métairon, Martin Kussmann, Mireille Moser

Consumption of low-carbohydrate, high-protein, high-fat diets lead to rapid weight loss but the cardioprotective effects of these diets have been questioned. We examined the impact of high-protein and high-fat diets on cholesterol metabolism by comparing t ...

Public Library of Science2012

Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Besides well-established roles of bile acids (BA) in dietary lipid absorption and cholesterol homeostasis, it has recently become clear that BA is also a biological signaling molecule. We have shown that strategies aimed at activating TGR5 by increasing th ...

Public Library of Science2012

Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response

Jacques Fellay, Qing Zhu

Low-density lipoprotein cholesterol (LDL-C) levels and interleukin 28B (IL28B) polymorphism are associated with sustained viral response (SVR) to peginterferon/ribavirin (pegIFN/RBV) for chronic hepatitis C (CHC) infection. IL28B has been linked with LDL-C ...

2012

The bile acid membrane receptor TGR5: a valuable metabolic target

Johan Auwerx, Kristina Schoonjans, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestines as well as in the circulation depending on food intake. Besides their role in dietary lipid absorption, BAs function as signaling ...

2011

Reducing distortions in diffusion-weighted echo planar imaging with a dual-echo blip-reversed sequence

Daniel Gallichan

The inherent distortions in echo-planar imaging that arise due to inhomogeneities in the static magnetic field can lead to difficulties when attempting to obtain structurally accurate diffusion-tensor imaging data. Parallel acceleration techniques can redu ...

Wiley-Blackwell2010

Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration

Melody Swartz, Joseph Rutkowski, Sai Reddy

Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid balance in the blood, ie, dyslipidem ...

American Society for Investigative Pathology2009

Effect of cholesterol on the structure of a phospholipid bilayer

Berend Smit

Cholesterol plays an important role in regulating the properties of phospholipid membranes. To obtain a detailed understanding of the lipid‚Äìcholesterol interactions, we have developed a mesoscopic water‚Äìlipid‚Äìcholesterol model. In this model, we take ...

2009

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary lipids. By using targeted somatic mutagenesis of the nuclear receptor liver receptor homolog 1 (LRH-1) in mouse hepatocytes, w ...

2007

Endocrine functions of bile acids

Johan Auwerx

Bile acids (BAs), a group of structurally diverse molecules that are primarily synthesized in the liver from cholesterol, are the chief components of bile. Besides their well-established roles in dietary lipid absorption and cholesterol homeostasis, it has ...

2006

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search