Publications associées à Agrégation des protéines

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

Nanomedicine requires in-depth knowledge of nanoparticle-protein interactions. These interactions are studied with methods limited to large or fluorescently labelled nanoparticles as they rely on scattering or fluorescence-correlation signals. Here, we hav ...

Nature Publishing Group2016

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Hilal Lashuel, Annalisa Ansaloni, Sophie Vieweg, John Blaine Warner IV

The first exon of the Huntingtin protein (Httex1) is one of the most actively studied Htt fragments because its overexpression in R6/2 transgenic mice has been shown to recapitulate several key features of Huntington disease. However, the majority of bioph ...

Amer Soc Biochemistry Molecular Biology Inc2016

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Françoise Gisou van der Goot Grunberg

Ubiquitin-specific protease 19 (USP19) is one of the deubiquitinating enzymes (DUBs) involved in regulating the ubiquitination status of substrate proteins. There are two major isoforms of USP19 with distinct C-termini; the USP19_a isoform has a transmembr ...

Public Library of Science2016

Physically based models to study the alkali-silica reaction

Karen Scrivener, Cyrille Dunant

The Laboratory of Construction Materials in Lausanne has been studying the alkali-silica reaction for more than 10 years, advancing the understanding of the reaction, and also producing microstructural models which can be used to predict quantitatively the ...

Ice Publishing2016

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Maurizio Molinari

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the unfolded protein response (UPR). The UPR enhances production of ER-resident chaperones and enzym ...

Nature Publishing Group2016

Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

Suliana Manley, Seamus John Holden

Although free-living and obligate intracellular bacteria are both polarized it is unclear whether the underlying polarization mechanisms and effector proteins are conserved. Here we dissect at the cytological, functional and structural level a conserved po ...

Elife Sciences Publications Ltd2016

Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach

Hans Peter Herzig, Elsie Barakat, Sara Santi

We present a study of the dynamics of protein aggregation using a Bloch surface wave (BSW) label-free sensing scheme. In a previous work, we demonstrated the ability to detect the early dynamic events of fibrillogenesis of amyloid beta-peptides (A beta), l ...

Spie-Int Soc Optical Engineering2015

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Hilal Lashuel, Bruno Claude Daniel Fauvet

Posttranslational modifications (PTMs) serve as molecular switches for regulating protein folding, function, and interactome and have been implicated in the misfolding and amyloid formation by several proteins linked to neurodegenerative diseases, includin ...

2015

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Agrégation des protéines

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

Physically based models to study the alkali-silica reaction

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Five Questions (with their Answers) on ER-Associated Degradation

Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein

Graph Chatbot

Chattez avec Graph Search

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Five Questions (with their Answers) on ER-Associated Degradation

Physically based models to study the alkali-silica reaction

A centrifugation-based physicochemical characterization method for the interaction between proteins and nanoparticles

Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

Modularity and determinants of a (bi-)polarization control system from free-living and obligate intracellular bacteria

Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery

Real-time Protein Aggregation Monitoring based on a Simultaneous Light Scattering Investigation and a Bloch Surface Wave-based Approach

Semisynthesis and Enzymatic Preparation of Post-translationally Modified α-Synuclein