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Publications associées (34)

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Christian Heinis, Xinjian Ji, Edward Jeffrey Will, Anne Sofie Luise Zarda, Alessandro Angelini, Alexander Lund Nielsen, Manuel Leonardo Merz, Mischa Schüttel, Ganesh Kumar Mothukuri, Zsolt Bognár

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Wiley-V C H Verlag Gmbh2024

Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins

Ghérici Hassaïne

Scaffold-based protein libraries are designed to be both diverse and rich in functional/folded proteins. However, introducing an extended diversity while preserving stability of the initial scaffold remains a challenge. Here we developed an original approa ...

NATURE PORTFOLIO2023

Generating macrocyclic inhibitors of protein-protein interactions

Gontran Sangouard

Protein-protein interactions (PPIs) play important roles in many diseases and their modulation is an attractive strategy for developing new therapeutics. However, the relatively large and often flat binding surfaces of PPIs makes the development of inhibit ...

EPFL2022

De novo developed small cyclic peptides that are orally available

Manuel Leonardo Merz

Cyclic peptides are ring-shaped molecules that emerged as a promising class of therapeutics. While it is often difficult to find small molecule binders for challenging disease targets, cyclic peptides can bind to featureless surfaces or inhibit protein-pro ...

EPFL2022

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Christian Heinis, Peter Matei Frisius Pânzar, Alexander Lund Nielsen, Manuel Leonardo Merz, Ganesh Kumar Mothukuri, Zsolt Bognár

Thiol groups are suitable handles for site-selectively modifying, immobilizing or cyclizing individual peptides or entire peptide libraries. A limiting step in producing the thiol-functionalized peptides is the chromatographic purification, which is partic ...

ROYAL SOC CHEMISTRY2022

Enclosure: Language-Based Restriction of Untrusted Libraries

James Richard Larus, Mathias Josef Payer, Edouard Bugnion, Evangelos Marios Kogias, Adrien Ghosn

Programming languages and systems have failed to address the security implications of the increasingly frequent use of public libraries to construct modern software. Most languages provide tools and online repositories to publish, import, and use libraries ...

2021

Methods for the generation of large combinatorial macrocycle libraries

Sevan Mleh Habeshian

Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

EPFL2021

Crosslingual Topic Modeling with WikiPDA

Robert West, Tiziano Piccardi

We present Wikipedia-based Polyglot Dirichlet Allocation (WikiPDA), a crosslingual topic model that learns to represent Wikipedia articles written in any language as distributions over a common set of language-independent topics. It leverages the fact that ...

ASSOC COMPUTING MACHINERY2021

Le maker, construction d’une figure politique de l’innovation en Chine urbaine

Florence Graezer Bideau, Clément Luc Guillaume Renaud

En Chine, les politiques urbaines se construisent autour d’une transition industrielle du modèle Made in China vers une nouvelle modernité centrée sur l’innovation technologique. Les discours accompagnant ces vastes réformes mettent en scène de nouvelles f ...

2020

SCALE/AMPX multigroup libraries for sodium-cooled fast reactor systems

Andreas Pautz, Winfried Zwermann, Friederike Bostelmann

New multigroup cross section libraries and associated covariance files that are optimized for the analysis of sodium-cooled fast reactors were generated with the AMPX tools distributed with the SCALE code system. These new libraries account for the fast ne ...

PERGAMON-ELSEVIER SCIENCE LTD2020

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