Publications associées à Bibliothèque publique

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Gerardo Turcatti, Julien Bortoli Chapalay, Xudong Kong, Van Manh Pham, Patrick Andreas Gonschorek, Sangram Shivdas Kale, Milan Bergeron-Brlek, João Miguel Franco Machado

Macrocyclic compounds are an attractive modality for drug development, but the limited availability of large, structurally diverse macrocyclic libraries hampers the discovery of leads. Here, we describe the discovery of efficient macrocyclization reactions ...

2019

Rational design of a high-throughput droplet sorter

Tobias Schneider, Simon Sebastian Schütz

The high-throughput selection of individual droplets is an essential function in droplet-based microfluidics. Fluorescence-activated droplet sorting is achieved using electric fields triggered at rates up to 30 kHz, providing the ultra-high throughput rele ...

2019

SMoTherSpectre: Exploiting Speculative Execution through Port Contention

Babak Falsafi, Mathias Josef Payer, Atri Bhattacharyya

Spectre, Meltdown, and related attacks have demonstrated that kernels, hypervisors, trusted execution environments, and browsers are prone to information disclosure through micro-architectural weaknesses. However, it remains unclear as to what extent other ...

ACM2019

New Techniques for the Digitization of Art Historical Photographic Archives - the Case of the Cini Foundation in Venice

Frédéric Kaplan, Isabella Di Lenardo, Benoît Laurent Auguste Seguin

Numerous libraries and museums hold large art historical photographic collections, numbering millions of images. Because of their non-standard format, these collections pose special challenges for digitization. This paper address these difficulties by prop ...

2018

Quoted Staged Rewriting: A Practical Approach to Library-Defined Optimizations

Christoph Koch, Amir Shaikhha, Lionel Emile Vincent Parreaux

Staging has proved a successful technique for programmatically removing code abstractions, thereby allowing for faster program execution while retaining a high-level interface for the programmer. Unfortunately, techniques based on staging suffer from a num ...

ACM2017

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

Harm-Anton Klok

Cyclic peptide disulfides (CXC) are an important class of biomolecules. The conjugation of cyclic peptide disulfides to synthetic polymers, however, is often difficult due to the presence of the disulfide bond combined with other potentially reactive side ...

Royal Society of Chemistry2016

Live mammalian cell arrays

Matthias Lütolf, Sebastian Maerkl, Samy Gobaa, Kristina Pan Woodruff, Luis Miguel Fidalgo Rabanera

High-content assays have the potential to drastically increase throughput in cell biology and drug discovery, but handling and culturing large libraries of cells such as primary tumor or cancer cell lines requires expensive, dedicated robotic equipment. We ...

Nature Publishing Group2013

Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

Kai Johnsson, Simone Moser

Mycobacterium goes yeast: Target deconvolution of anti-tuberculosis drugs can be a very challenging task. Here we report a yeast 3-hybrid system that allows promising small molecules to be screened for protein targets of a pathogen in nontoxic yeast cells. ...

Wiley-V C H Verlag Gmbh2013

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Bibliothèque publique

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

A sequence-dependent coarse-grain model of B-DNA with explicit description of bases and phosphate groups parametrised from large scale Molecular Dynamics simulations

Rational design of a high-throughput droplet sorter

SMoTherSpectre: Exploiting Speculative Execution through Port Contention

New Techniques for the Digitization of Art Historical Photographic Archives - the Case of the Cini Foundation in Venice

Quoted Staged Rewriting: A Practical Approach to Library-Defined Optimizations

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

Live mammalian cell arrays

Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

Indole Alkaloids Synthesis via a Selective Cyclization of Aminocyclopropanes

Graph Chatbot

Chattez avec Graph Search

A sequence-dependent coarse-grain model of B-DNA with explicit description of bases and phosphate groups parametrised from large scale Molecular Dynamics simulations

New Techniques for the Digitization of Art Historical Photographic Archives - the Case of the Cini Foundation in Venice

Indole Alkaloids Synthesis via a Selective Cyclization of Aminocyclopropanes

SMoTherSpectre: Exploiting Speculative Execution through Port Contention

Rational design of a high-throughput droplet sorter

Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets

Synthesis of cyclic peptide disulfide-PHPMA conjugates via sequential active ester aminolysis and CuAAC coupling

Quoted Staged Rewriting: A Practical Approach to Library-Defined Optimizations

Thiol-to-amine cyclization reaction enables screening of large libraries of macrocyclic compounds and the generation of sub-kilodalton ligands

Live mammalian cell arrays