Concept

Tyrosinase

Publications associées (49)

Soft probes for bio-electrochemical imaging

The aim of bioimaging is to visualize properties and processes of living objects or biological samples and extracts image-related information for revealing important physical structures or map the distribution of specific biomolecules in tissues for clinic ...

EPFL2017

Micro- and nanoscale hierarchical structure of core-shell protein microgels

Giovanni Dietler, Francesco Simone Ruggeri, Raffaele Mezzenga

Protein nanofibrils were first discovered in the context of misfolding and neurodegenerative diseases but have recently been found in naturally occurring functional materials including algal adhesives, bacterial coatings, and even mammalian melanosomes. Th ...

Royal Soc Chemistry2016

Multiple scanning electrochemical microscopy mapping of tyrosinase in micro-contact printed fruit samples on polyvinylidene fluoride membrane

Hubert Girault, Andreas Stephan Lesch, Liang Qiao, Fernando Cortes Salazar, Tzu-En Lin, Alexandra Bondarenko

Herein, we introduce three orthogonal and compatible methods for detecting tyrosinase, a key factor in fruit browning and skin disorders, with high spatial resolution by means of scanning electrochemical microscopy (SECM). All methods are performed subsequ ...

Elsevier2015

Coat color dilution in mice because of inactivation of the melanoma antigen MART-1

Friedrich Beermann, Iraz Toprak Aydin

Melanoma antigen recognized by T cells 1 (MART-1) is a melanoma-specific antigen, which has been thoroughly studied in the context of immunotherapy against malignant melanoma and which is found only in the pigment cell lineage. However, its exact function ...

2012

Constitutive gray hair in Mice induced by Melanocyte-specific deletion of c-Myc

Friedrich Beermann, Karine Schouwey, Marzia Armaro

c-Myc is involved in the control of diverse cellular processes and implicated in the maintenance of different tissues including the neural crest. Here we report that c-Myc is particularly important for pigment cell development and homeostasis. Targeting c- ...

2012

Surface Functionalisation of Alumina Ceramic Foams with Organic Ligands

Sandrine Gerber, Vincent Laporte, Pascal Miéville, Françoise Borcard, Marc Anthony Caporini

Different anchoring groups have been studied with the aim of covalently binding organic linkers to the surface of alumina ceramic foams. The results suggested that a higher degree of functionalisation was achieved with a pyrogallol derivative - as compared ...

2012

Method and compositions for inhibition of macrophage migration inhibitory factor (mif)

Hilal Lashuel, Hajer Ouertatani-Sakouhi

The present invention relates to methods for inhibition of tautomerase activity of macrophage migration inhibitory factor (MIF). The invention further relates to substances for irreversibly covalently binding to MIF for inhibition of tautomerase activity. ...

2011

Regulation of DHICA-mediated antioxidation by dopachrome tautomerase: Implication for skin photoprotection against UVA radiation

Friedrich Beermann

Dopachrome tautomerase (Dct) is a critical enzyme in the melanogenesis pathway that isomerizes the intermediate dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) and influences the proportion of DHICA monomer incorporated into the 5,6-dihydroxyin ...

Elsevier2010

Key roles for transforming growth factor beta in melanocyte stem cell maintenance

Friedrich Beermann

Melanocyte stem cells in the bulge area of hair follicles are responsible for hair pigmentation, and defects in them cause hair graying. Here we describe the process of melanocyte stem cell entry into the quiescent state and show that niche-derived transfo ...

2010

Intramolecular Suzuki-Miyaura reaction for the total synthesis of signal peptidase inhibitors, arylomycins A2 and B2

Jieping Zhu

Development of the total syntheses of arylomycins A1 and B2 is detailed. Key features of our approach include (1) formation of 14-membered meta,meta-cyclophane by an intramol. Suzuki-Miyaura reaction; (2) incorporation of N-Me-4-hydroxyphenylglycine into t ...

2010

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