Concept

Azide-alkyne Huisgen cycloaddition

Publications associées (57)

Antiproliferative Activity of Gold(I) Alkyne Complexes Containing Water-Soluble Phosphane Ligands

Paul Joseph Dyson, Angela Casini, Olivier Pierre Zava, elena vergara

A series of mono-, di-, and trinuclear organometallic alkynyl phosphane gold(I) complexes contg. the stable and water-sol. PTA and DAPTA ligands have been synthesized and characterized. The solid-state structure of one of these compds. was also established ...

American Chemical Society2010

Chemoselective C-H Bond Activation: Ligand and Solvent Free Iron-Catalyzed Oxidative C-C Cross-Coupling of Tertiary Amines with Terminal Alkynes. Reaction Scope and Mechanism

Pierre Vogel, Chandra Mouleeswara Rao Volla

FeCl2 catalyzes the oxidative C-C cross-coupling of tertiary amines with terminal alkynes into propargylamines using (t-BuO)2 as oxidant. The reaction can be applied to aromatic and aliphatic amines and alkynes without solvent. High chemoselectivity for am ...

2009

Iron/copper-catalyzed C–C cross-coupling of aryl iodides with terminal alkynes

Pierre Vogel, Chandra Mouleeswara Rao Volla

Synergic effect of iron and copper salts as catalysts for the Sonogashira–Hagihara cross-couplings of aryl iodides with terminal alkynes is demonstrated. High yields of cross- coupled products are obtained under conditions that are smoother than those usin ...

2008

The reaction of alkynes with triangulo-clusters [Pt3(m-CO)3(PR3)3]

Gabor Laurenczy, Raymond Roulet, Kurt Schenk, Serena Detti

The reaction of the cluster complexes [Pt-3(mu -CO)(3)(PR3)(3)] (PR3 = PPh3 1, PPh(2)Bz 2, PCy3 3 and P(i)pr(3) 4) with dialkyl acetylenedicarboxylate, R'O2CC drop CCO2R' (R= CH3 or Bu-t) have been examined under various conditions. At low temperature the ...

2001

A novel aldol condensation alternative: a,b-unsaturated aldehydes from 3-hydroxy-1-alkynes via dihydrodioxepins

The controlled aldol condensation between an aliph. ketone and an acetaldehyde equiv. remains a challenge. One soln. to this evergreen problem consists of the nucleophilic addn. of acetylene to the ketone and the subsequent isomerization of the resulting 3 ...

1998

gem-Difluorocyclopropenes by [1+2] cycloaddition reactions between difluorocarbene and acetylenes having terminal or internal triple bonds

Difluorocarbene, generated from (bromodifluoromethyl)triphenlphosphonium bromide, underwent cycloaddn. to RC.tplbond.CR1 (R = Ph, hexyl, octyl, R1 = H; R = Pr, R1 = Me, propyl; R = Ph, R1 = Me) to give difluorocyclopropenes I in 46-80% yields. [on SciFinde ...

1991

Alcoholate Clusters ("Aggregates") and Their Role in Alkyne Forming Elimination Reactions

Kinetic data for the dehydrochlorination of (E)- and (Z)-MeCH:CClC.tplbond.CCMe3 by KOCMe3 (I) in different solvents suggested that I assocs. participated in a push-pull, conveyor-belt mechanism. MeC.tplbond.CC.tplbond.CCMe3 was the only product from both ...

1981

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