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The formation and further reactions of halamines during oxidative water treatment can be relevant for water quality. In this study, we investigated the formation and reactivity of several inorganic and organic halamines (monochloramine, N-chloromethylamine ...
Transition-metal catalysed enantioselective CâH functionalisations enable rapid increase of molecular complexity via non-classical disconnections. This thesis describes the development of intramolecular Pd(0)-catalysed C-H functionalisations for the asym ...
Vicinal amino alcohols and diamines are privileged motifs in organic chemistry. As such, they have been targets of choice for exploring and developing novel and more efficient strategies in organic synthesis. In this context, the difunctionalization of ole ...
The base-catalyzed intramolecular hydroamination of 1-ethylaminocyclohexa-2,5-dienes is described. The transformation proceeds through isomerization of the cyclohexa-1,4-dienyl fragment into the corresponding conjugated 1,3-diene prior to the hydroaminatio ...
Many abundant and highly bioactive natural alkaloids contain an indolizidine skeleton. A simple, high yielding method to synthesize this scaffold from N-heterocycles was developed. A wide range of pyridines, quinolines and isoquinolines reacted with donor- ...
We previously reported the synthesis and the antimycobacterial activity of 4-(7,7-dimethyl-7H-furo[3,2-f]chromen-2-yl)pyridine. From this result, we sought to design simple synthetic accesses to related structures allowing the preparation of a diverse set ...
We present a novel method, canonical adiabatic free energy sampling (CAFES) that allows for the efficient exploration of the free energy surface of a subsystem (S) embedded in an environment (E) using mol. dynamics simulations. The dynamics of S is decoupl ...
Ru(II)-η6-p-cymene compds. bearing pyrone-derived ligands, which were obtained by Mannich reactions between kojic acid and piperidine or morpholine analogs, have been synthesized. The compds. were characterized by NMR spectroscopy, mass spectrometry, therm ...
Using in situ generated iodine fluoride as the reagent, bromine can be replaced by fluorine at carbocation-sustaining sites. Iodine fluoride or, being its operational equiv., the mixt. of N-iodosuccinimide and triethylamine tris(hydrogen fluoride) reacts w ...
An improved method for the prepn. of Me2C:CFCO2Et is described. The two stereoisomers (E)- and (Z)-BrCH2CMe:CFCO2Et obtained by g-bromination are sepd. and can be individually converted into the corresponding phosphonates. The PO-ylides generated by a-depr ...
