Concept
Métathèse des alcènes
Publications associées (117)
Synthesis and Reactivity of an Anionic Diazoolefin
Rosario Scopelliti, Kay Severin, Farzaneh Fadaei Tirani, Bastiaan Kooij, Zhaowen Dong
Bent (hetero)allenes such as carbodicarbenes and carbodiphosphoranes can act as neutral C-donor ligands, and diverse applications in coordination chemistry have been reported. N-Heterocyclic diazoolefins are heterocumulenes, which can function in a similar ...
2023Modular Synthesis of Benzocyclobutenes via Pd(II)-Catalyzed Oxidative [2+2] Annulation of Arylboronic Acids with Alkenes
Qian Wang, Jieping Zhu, Takuji Fujii, Simone Gallarati
Benzocyclobutenes (BCBs) are highly valuable compounds in organic synthesis, medicinal chemistry, and materials science. However, catalytic modular synthesis of functionalized BCBs from easily accessible starting materials remains limited. We report herein ...
2022Pd(II)-Catalyzed Aminoacetoxylation of Alkenes Via Tether Formation
Jérôme Waser, Stefano Nicolai, Ashis Kumar Das, Thomas Rossolini
A Pd-catalyzed method based on the use of a molecular tether is described for olefin difunctionalization. Enabled by an easily introduced trifluoroacetaldehyde-derived tether, a simultaneous introduction of oxygen and nitrogen heteroatoms across unsaturate ...
2022Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes
Xile Hu, Chao Fan, Srikrishna Bera, Zhikun Zhang
Compounds rich in sp(3)-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleo ...
AMER CHEMICAL SOC2022Ring-Opening Reactions of Aminocyclopropanes and Aminocyclobutanes
Nitrogen-containing compounds are an important class of molecules in medicinal chemistry, chemical biology, biochemistry, material sciences or environmental sciences. Organic nitrogen occurs in many forms, ranging from small building blocks such as urea, a ...
EPFL2022Asymmetric Cyclopropanation and Epoxidation via a Catalytically Formed Chiral Auxiliary
For the enantioselective diversification of a single starting material, a different chiral catalyst is usually required for each transformation. Herein, we extend the concept of catalytically formed chiral auxiliary from hydrogenation to the asymmetric cyc ...
WILEY-V C H VERLAG GMBH2022Development of C-C and C-O bond cleavage catalysts for the depolymerization of plastics
Chemical recycling of plastics provides more flexibility for materials circulation than landfill disposal or incineration. Intensive research efforts have been devoted to maximizing the efficiency of chemical recycling through catalyst development. The fro ...
EPFL2022Apparent 6-endo-trig Carbofluorination of Alkenes Enabled by Palladium-Based Dyotropic Rearrangement
Qian Wang, Jieping Zhu, Jing Gong
Alkene difunctionalization featuring an intramolecular carbometallation step has been developed into a powerful transformation in organic synthesis. The 5-exo-trig carbometallation is in general highly favored over the alternative 6-endo-trig cyclization. ...
WILEY-V C H VERLAG GMBH2022