Concept

Genetic correlation

Publications associées (47)

EEG microstates are a candidate endophenotype for schizophrenia

Michael Herzog, Christine Mohr, Maya Roinishvili, Ophélie Gladys Favrod, Patricia Figueiredo

Electroencephalogram microstates are recurrent scalp potential configurations that remain stable for around 90 ms. The dynamics of two of the four canonical classes of microstates, commonly labeled as C and D, have been suggested as a potential endophenoty ...

2020

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

Jacques Fellay, Christian Hammer, Flavia Aurelia Shoko Hodel, Petar Scepanovic

Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total ...

2019

The individual structure of visual space

Michael Herzog, Aline Françoise Cretenoud, Gregory Francis, Lukasz Grzeczkowski

Common factors are ubiquitous. First, we show that, however in vision, correlations of performance in similar paradigms are low even though test-retest reliability is high. Second, one might expect that correlations increase with increasing age because of ...

2018

Genetic determinants of healthy human immune variance: from humoral response to microbiome diversity

Petar Scepanovic

Identifying the drivers of the observed interindividual variability of the human immune system is crucial to our understanding of infectious and immune-mediated diseases. The contribution of genetic and non-genetic factors to immunological differences betw ...

EPFL2018

About specific and general factors for visual illusions

Michael Herzog, Aline Françoise Cretenoud, Gregory Francis, Lukasz Grzeczkowski

Contrary to studies of audition and cognition, we previously did not find evidence for a general common factor for vision but for many very specific ones. For example, we found strong correlations between 19 versions of the Ebbinghaus illusion, which diffe ...

2018

Experimental evolution of slowed cognitive aging in Drosophila melanogaster

Brian Dennis Hollis

Reproductive output and cognitive performance decline in parallel during aging, but it is unknown whether this reflects a shared genetic architecture or merely the declining force of natural selection acting independently on both traits. We used experiment ...

2017

Efficient inference for genetic association studies with multiple outcomes

Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux

Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single clinical outcome on ma ...

Oxford University Press2017

Inequality in genetic cancer risk suggests bad genes rather than bad luck

Mats Julius Stensrud

Heritability is often estimated by decomposing the variance of a trait into genetic and other factors. Interpreting such variance decompositions, however, is not straightforward. In particular, there is an ongoing debate on the importance of genetic factor ...

2017

Host and pathogen genomics of severe pediatric infections

Samira Asgari

Infectious diseases are among the leading causes of human morbidity and mortality, with the greatest burden felt in the pediatric population. For any infectious disease, only a fraction of the exposed individuals develop clinical symptoms. These inter-indi ...

EPFL2016

Cognitive markers as potential endophenotypes for schizophrenia

Michael Herzog, Maya Roinishvili

Schizophrenia is a heterogeneous disease strongly influenced by genetic predisposition. A large variety of candidate genes has been identified of which each gene, however, explains only a small proportion of the genetic risk. For this reason, stable marker ...

2016

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