Cementoenamel junction (CEJ) is defined as the area of the union of cementum and enamel at the cervical region of the tooth. It is a slightly visible anatomical border identified on a tooth. It is the location where the enamel, which covers the anatomical crown of a tooth, and the cementum, which covers the anatomical root of a tooth, meet. Informally it is known as the neck of the tooth.The border created by these two dental tissues has much significance as it is usually the location where the gingiva attaches to a healthy tooth by fibers called the gingival fibers. Active recession of the gingiva reveals the cementoenamel junction in the mouth and is usually a sign of an unhealthy condition. The loss of attachment is considered a more reliable indicator of periodontal disease. The CEJ is the site of major tooth resorption. A significant proportion of tooth loss is caused by tooth resorption, which occurs in 5 to 10 percent of the population. The clinical location of CEJ which is a static landmark, serves as a crucial anatomical site for the measurement of probing pocket depth (PPD) and clinical attachment level (CAL). The CEJ varies between subjects, but also between teeth from the same person. There exists a normal variation in the relationship of the cementum and the enamel at the cementoenamel junction. In about 60–65% of teeth, the cementum overlaps the enamel at the CEJ, while in about 30% of teeth, the cementum and enamel abut each other with no overlap. In only 5–10% of teeth, there is a space between the enamel and the cementum at which the underlying dentin is exposed. In the tooth bud, regions where enamel formation is completed, the enamel organ gives rise to Hertwig's epithelial root sheath, composed of two epithelial layers derived from the external and internal epithelia. The sheath is irregularly fragmented in time and space as it promotes cementum deposition on the newly formed dentin. After this fragmentation, Hertwig's epithelial root sheath also participates in cementogenesis and formation of the periodontal ligament, giving rise to the epithelial rests of Malassez.