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Publications associées (50)

Perturbations of the Straight Transmembrane alpha-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by gamma-Secretase

Matteo Dal Peraro, Patrick Fraering, Mitko Dimitrov, Thomas Lemmin

Background: Amyloid- neurotoxicity depends on the specificity of the proteolytic cleavage of the amyloid precursor protein (APP) transmembrane domain. Results: The APP transmembrane -helix is straight in a biological membrane bilayer. Conclusion: The flexi ...

American Society for Biochemistry and Molecular Biology2014

Bilayer splitting and wave functions symmetry in Sr3Ir2O7

Henrik Moodysson Rønnow, Marco Grioni, Johan Juul Chang, Luca Moreschini, Simon Karl Moser, Bastien Dalla Piazza

The influence of dimensionality on the electronic properties of layered perovskite materials remains an outstanding issue. We address it here for Sr3Ir2O7, the bilayer compound of the iridate Srn+1IrnO3n+1 series. By angle-resolved photoemission spectrosco ...

Amer Physical Soc2014

Amphiphilic amino acids: a key to adsorbing proteins to nanopatterned surfaces?

Francesco Stellacci

It has been suggested that amphiphilic amino acids play an important role in the adsorption of proteins on nanostructured surfaces with an ordered, striped domain structure such as those presented by monolayer-protected metal nanoparticles (MPMNs). We have ...

Royal Soc Chemistry2013

Vesicle Photonics

Demetri Psaltis, Sylvie Roke, Jeffrey Alan Hubbell, Andreas Vasdekis

Amphiphiles, under appropriate conditions, can self-assemble into nanoscale thin membrane vessels (vesicles) that encapsulate and hence protect and transportmolecular payloads.Vesicles assemble naturally within cells but can also be artificially synthesize ...

Annual Reviews2013

Vesicles and Vesicle Fusion: Coarse-Grained Simulations

Julian Charles Shillcock

Biological cells are highly dynamic, and continually move material around their own volume and between their interior and exterior. Much of this transport encapsulates the material inside phospholipid vesicles that shuttle to and from, fusing with, and bud ...

Humana Press2013

Spontaneous Vesicle Self-Assembly: A Mesoscopic View of Membrane Dynamics

Amphiphilic vesicles are ubiquitous in living cells and industrially interesting as drug delivery vehicles. Vesicle self-assembly proceeds rapidly from nanometer to micrometer length scales and is too fast to image experimentally but too slow for molecular ...

American Chemical Society2012

On the Equivalence of Schemes for Simulating Bilayers at Constant Surface Tension

Berend Smit

Lipid bilayers are simulated using flexible simulation cells in order to allow for relaxations in area per lipid as bilayer content and temperature are varied. We develop a suite of Monte Carlo (MC) moves designed to generate constant surface tension γ and ...

2012

Understanding the Phase Behavior of Coarse-Grained Model Lipid Bilayers through Computational Calorimetry

Berend Smit

We study the phase behavior of saturated lipids as a function of temperature and tail length for two coarse-grained models: the soft-repulsive model typically employed with dissipative particle dynamics (DPD) and the MARTINI model. We characterize the simu ...

2012

An array of 100 μm × 100 μm dielectric elastomer actuators with 80% strain for tissue engineering applications

Herbert Shea, Samin Akbari

Biological cells modulate their behavior, express genes, proliferate or differentiate in response to mechanical strains ranging from 1% to 20%. There currently exists no technique to apply strain to many targeted individual cells in a larger culture in ord ...

Elsevier2012

Connecting vesicular transport with lipid synthesis: FAPP2

Giovanni D'Angelo

Next to the protein-based machineries composed of small G-proteins, coat complexes, SNAREs and tethering factors, the lipid-based machineries are emerging as important players in membrane trafficking. As a component of these machineries, lipid transfer pro ...

2012

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