Concept

Maladie auto-immune

Publications associées (192)

Biomaterial Strategies for Immunomodulation

Strategies to enhance, suppress, or qualitatively shape the immune response are of importance for diverse biomedical applications, such as the development of new vaccines, treatments for autoimmune diseases and allergies, strategies for regenerative medici ...

Annual Reviews2015

Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens

Bruno Lemaitre, Sveta Chakrabarti, Sylvain Kolly

The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unkno ...

Wiley-Blackwell2015

Effects of PVA coated nanoparticles on human immune cells

Heinrich Hofmann, Lionel André Maurizi

Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There is an urgent nee ...

Dove Medical Press Ltd2015

Engineering antigen-specific immunological tolerance

Stephane Kontos, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We pr ...

Current Biology Ltd2015

Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies

Philippe Renaud, Anja Kunze, Yufei Ren

Compartmentalized microfluidic devices are designed to engineer the cellular environment for cell cultures. The practical use of the compartmentalized chambers can be expanded to induce co-pathological cell cultures, where one cell population expresses a s ...

Springer New York2015

Antiviral treatment of feline immunodeficiency virus-infected cats with (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine

Johan Auwerx

Feline immunodeficiency virus (FIV), the causative agent of an acquired immunodeficiency syndrome in cats (feline AIDS), is a ubiquitous health threat to the domestic and feral cat population, also triggering disease in wild animals. No registered antivira ...

Elsevier2015

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Stephane Kontos, Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with apoptotic debris are known to be processed tolerogenically ...

Nature Publishing Group2015

Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor

Freddy Radtke, Christian Heinis, Charlotte Marie Urech-Varenne

Precise regulation of the Notch signaling pathway is crucial, as increases or deficiencies in signaling are associated with diseases, including a wide range of cancers. Recent studies have demonstrated that monoclonal antibodies that bind and stabilize the ...

Wiley-Blackwell2015

Structural and Mechanistic Paradigm of Leptin Receptor Activation Revealed by Complexes with Wild-Type and Antagonist Leptins

Henning Paul-Julius Stahlberg

Leptin activates its cognate receptor (LR) to regulate body weight and metabolically costly processes, such as reproduction and immune responses. Despite such benevolent pleiotropy, leptin-mediated signaling has been implicated in autoimmune diseases and b ...

Elsevier BV2014

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

Andrea Ablasser

Cytosolic detection of DNA is crucial for the initiation of antiviral immunity but can also cause autoimmunity in the context of endogenous nucleic acids being sensed. Mutations in the human 3' repair exonuclease 1 (TREX1) have been linked to the type I IF ...

2014

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