Concept
Microévolution et macroévolution
Publications associées (13)
Genomic consequences of colonisation, migration and genetic drift in barn owl insular populations of the eastern Mediterranean
Nicolas Jean Philippe Guex, Eléonore Lavanchy
The study of insular populations was key in the development of evolutionary theory. The successful colonisation of an island depends on the geographic context, and specific characteristics of the organism and the island, but also on stochastic processes. A ...
2022The genetic architecture of complex human traits at the dawn of genomic medicine
The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine.
The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...
EPFL2021Linking micro and macroevolution in the presence of migration
Sophie Myriam Hautphenne, Laurent Lehmann, Nicolas Salamin
Understanding macroevolutionary patterns is central to evolutionary biology. This involves the process of divergence within a species, which starts at the microevolutionary level, for instance, when two sub populations evolve towards different phenotypic o ...
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD2020Evolution of longevity improves immunity in Drosophila
Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute to variation in longevity. For example, analysis of mutants and transgenes has identified insulin ...
JOHN WILEY & SONS LTD2018Multiscale landscape genomic models to detect signatures of selection in the alpine plant Biscutella laevigata
Stéphane Joost, Kevin Leempoel
Plant species are known to adapt locally to their environment, particularly in mountainous areas where conditions can vary drastically over short distances. The climate of such landscapes being largely influenced by topography, using fine-scale models to e ...
2018A unified measure of linear and nonlinear selection on quantitative traits
Lande and Arnold's approach to quantifying natural selection has become a standard tool in evolutionary biology due to its simplicity and generality. It treats linear and nonlinear selection in two separate frameworks, generating coefficients of selection ...
Wiley2017TEMPLE: analysing population genetic variation at transcription factor binding sites
Stefan Jean Laurent, Maria Litovchenko
Genetic variation occurring at the level of regulatory sequences can affect phenotypes and fitness in natural populations. This variation can be analysed in a population genetic framework to study how genetic drift and selection affect the evolution of the ...
Wiley-Blackwell2016Molecular Analysis of NOTCH2 in Patients with Primary Open-Angle Glaucoma
Background and Purpose: Transgenic mice over-expressing Notch2 in the uvea exhibit a hyperplastic ciliary body leading to increased IOP and glaucoma. The aim of this study was to investigate the possible presence of NOTCH2 variants in patients with primary ...
Georg Thieme Verlag Kg2015Distinct invasion strategies operating within a natural annual plant system
Thomas Spiegelberger, Justine Marie Gay des Combes
Alien plant species are known to have a wide range of impacts on recipient communities, from resident species' exclusions to coexistence with resident species. It remains unclear; however, if this variety of impacts is due to different invader strategies, ...
Wiley-Blackwell2015Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective
Jeffrey David Jensen, Matthieu Foll, Claudia Bank, Hyunjin Shim, Gregory Bruce Ewing, Anna Ferrer Admetlla
Author Summary In recent years, considerable attention has been given to the evolution of drug resistance in the influenza A H1N1 strain. As a major annual cause of morbidity and mortality, combined with the rapid global spread of drug resistance, influenz ...
Public Library of Science2014