Réseau du mode par défaut | EPFL Graph Search

vignette|Modèle anatomique et fonctionnel du réseau du mode par défaut (2019). Chaque gommette, par sa taille et sa couleur, indique l’importance de cette région dans le réseau en mode par défaut. VMPFC cortex préfrontal ventromédian, AMPFC cortex préfrontal antérieur médian, DPFC cortex préfrontal dorsal, PCC, cortex cingulaire postérieur, PPC cortex pariétal postérieur, C noyau caudé, Rsp cortex rétrospénial, T thalamus, BF cerveau antérieur basal, VLPFC cortex préfrontal ventro-latéral, Amy amygdale, MidB mésencéphale, PH région parahippocampique, MTG gyrus temporal, TP, pôle temporal, CbH hémisphère cérébelleux (cervelet), CbT tonsil cérébelleux. Le réseau du mode par défaut (MPD) désigne, en neurosciences, un réseau constitué des régions cérébrales actives lorsqu'un individu n'est pas focalisé sur le monde extérieur, et lorsque le cerveau est au repos, mais actif. Les termes de réseau par défaut, réseau d'état par défaut, réseau d'absence de tâche, et réseau cérébral du mode par

Dynamic functional brain networks underlying the temporal inertia of negative emotions

Thomas William Arthur Bolton, Julian Gaviria, Gwladys Rey, Dimitri Nestor Alice Van De Ville

Affective inertia represents the lasting impact of transient emotions at one time point on affective state at a subsequent time point. Here we describe the neural underpinnings of inertia following negative emotions elicited by sad events in movies. Using a co-activation pattern analysis of dynamic functional connectivity, we examined the temporal expression and reciprocal interactions among brain-wide networks during movies and subsequent resting periods in twenty healthy subjects. Our findings revealed distinctive spatiotemporal expression of visual (VIS), default mode (DMN), central executive (CEN), and frontoparietal control (FPCN) networks both in negative movies and in rest periods following these movies. We also identified different reciprocal relationships among these networks, in transitions from movie to rest. While FPCN and DMN expression increased during and after negative movies, respectively, FPCN occurrences during the movie predicted lower DMN and higher CEN expression during subsequent rest after neutral movies, but this relationship was reversed after the elicitation of negative emotions. Changes in FPCN and DMN activity correlated with more negative subjective affect. These findings provide new insights into the transient interactions of intrinsic brain networks underpinning the inertia of negative emotions. More specifically, they describe a major role of FPCN in emotion elicitation processes, with prolonged impact on DMN activity in subsequent rest, presumably involved in emotion regulation and restoration of homeostatic balance after negative events.

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Brain functional connectivity dynamics at rest in the aftermath of affective and cognitive challenges

Thomas William Arthur Bolton, Julian Gaviria, Gwladys Rey, Dimitri Nestor Alice Van De Ville

Carry-over effects on brain states have been reported following emotional and cognitive events, persisting even during subsequent rest. Here, we investigated such effects by identifying recurring co-activation patterns (CAPs) in neural networks at rest with functional magnetic resonance imaging (fMRI). We compared carry-over effects on brain-wide CAPs at rest and their modulation after both affective and cognitive challenges. Healthy participants underwent fMRI scanning during emotional induction with negative valence and performed cognitive control tasks, each followed by resting periods. Several CAPs, overlapping with the default-mode (DMN), salience, dorsal attention, and social cognition networks were impacted by both the preceding events (movie or task) and the emotional valence of the experimental contexts (neutral or negative), with differential dynamic fluctuations over time. Temporal metrics of DMN-related CAPs were altered after exposure to negative emotional content (compared to neutral) and predicted changes in subjective affect on self-reported scores. In parallel, duration rates of another attention-related CAP increased with greater task difficulty during the preceding cognitive control condition, specifically in the negative context. These findings provide new insights on the anatomical organization and temporal inertia of functional brain networks, whose expression is differentially shaped by emotional states, presumably mediating adaptive homeostatic processes subsequent to behaviorally challenging events.

WILEY2020

Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states

Thomas William Arthur Bolton, Julian Gaviria, Maria Giulia Preti, Gwladys Rey, Dimitri Nestor Alice Van De Ville

Alterations in activity and connectivity of brain circuits implicated in emotion processing and emotion regulation have been observed during resting-state for different clinical phases of bipolar disorders (BD), but longitudinal investigations across different mood states in the same patients are still rare. Furthermore, measuring dynamics of functional connectivity patterns offers a powerful method to explore changes in the brain's intrinsic functional organization across mood states. We used a novel co-activation pattern (CAP) analysis to explore the dynamics of amygdala connectivity at rest in a cohort of 20 BD patients prospectively followed-up and scanned across distinct mood states: euthymia (20 patients; 39 sessions), depression (12 patients; 18 sessions), or mania/hypomania (14 patients; 18 sessions). We compared them to 41 healthy controls scanned once or twice (55 sessions). We characterized temporal aspects of dynamic fluctuations in amygdala connectivity over the whole brain as a function of current mood. We identified six distinct networks describing amygdala connectivity, among which an interoceptive-sensorimotor CAP exhibited more frequent occurrences during hypomania compared to other mood states, and predicted more severe symptoms of irritability and motor agitation. In contrast, a default-mode CAP exhibited more frequent occurrences during depression compared to other mood states and compared to controls, with a positive association with depression severity. Our results reveal distinctive interactions between amygdala and distributed brain networks in different mood states, and foster research on interoception and default-mode systems especially during the manic and depressive phase, respectively. Our study also demonstrates the benefits of assessing brain dynamics in BD.

SPRINGERNATURE2021

Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states

Thomas William Arthur Bolton, Julian Gaviria, Maria Giulia Preti, Gwladys Rey, Dimitri Nestor Alice Van De Ville

SPRINGERNATURE2021