Concept

Hydrogénase

Publications associées (46)

Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms

Christof Holliger, Julien Maillard, Romain Hamelin, Mathilde Stéphanie Willemin, Florence Armand

IntroductionDesulfitobacterium hafniense was isolated for its ability to use organohalogens as terminal electron acceptors via organohalide respiration (OHR). In contrast to obligate OHR bacteria, Desulfitobacterium spp. show a highly versatile energy meta ...

FRONTIERS MEDIA SA2023

The Function of Two Radical-SAM Enzymes, HcgA and HcgG, in the Biosynthesis of the [Fe]-Hydrogenase Cofactor

Xile Hu, Huijie Pan, Yiwei Zheng

In the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor, 6-carboxymethyl-5-methyl-4-hydroxy-2-pyridinol (1) is 3-methylated to form 2, then 4-guanylylated to form 3, and converted into the full cofactor. HcgA-G proteins catalyze the biosynthetic ...

WILEY-V C H VERLAG GMBH2022

High-Valent Nickel Promoted by Atomically Embedded Copper for Efficient Water Oxidation

Jun Li, Ning Wang, Yun Liu, Bo Zhang

Efficient and low-cost electrocatalysts for oxygen evolution reaction (OER), particularly in neutral conditions, are of significant importance for renewable energy technologies such as CO2 reduction and seawater splitting electrolysis. High-valent transiti ...

AMER CHEMICAL SOC2020

A catalytically active [Mn]-hydrogenase incorporating a non-native metal cofactor

Xile Hu, Farzaneh Fadaei Tirani, Matthew Wodrich, Huijie Pan

Nature carefully selects specific metal ions for incorporation into the enzymes that catalyse the chemical reactions necessary for life. Hydrogenases, enzymes that activate molecular H-2, exclusively utilize Ni and Fe in [NiFe]-, [FeFe]- and [Fe]-hydrogean ...

2019

The atomic-resolution crystal structure of activated [Fe]-hydrogenase

Xile Hu, Matthew Wodrich

Hydrogenases are promising templates for constructing new H-2-based catalysts. [Fe]-hydrogenase, which features an ironguanylylpyridinol (FeGP) cofactor, catalyses a reversible hydride transfer from H-2 to methenyl-tetrahydromethanopterin (methenyl-H4MPT+, ...

NATURE PUBLISHING GROUP2019

Towards artificial methanogenesis: biosynthesis of the [Fe]-hydrogenase cofactor and characterization of the semisynthetic hydrogenase

Xile Hu, Lichen Bai, Tao Xu

The greenhouse gas and energy carrier methane is produced on Earth mainly by methanogenic archaea. In the hydrogenotrophic methanogenic pathway the reduction of one CO2 to one methane molecule requires four molecules of H-2 containing eight electrons. Four ...

Royal Soc Chemistry2017

Natural inspirations for metal–ligand cooperative catalysis

Xile Hu, Matthew Wodrich

In conventional homogeneous catalysis, supporting ligands act as spectators that do not interact directly with substrates. However, in metal–ligand cooperative catalysis, ligands are involved in facilitating reaction pathways that would be less favourable ...

2017

Natural inspirations for metal–ligand cooperative catalysis

Xile Hu, Matthew Wodrich

2017

Characterization of iron reduction in Clostridium acetobutylicum mutants obtained by targeted and transposon mutagenesis

Matthieu Jonas Valentin Amos

Iron reduction in Gram-positive bacteria is not well understood yet, even if it has been investigated in some extent for Gram-positive bacteria. The mechanisms involved in the delivery of electrons to a solid terminal electron acceptor like iron oxides hav ...

2017

A Functional Model of [Fe]-Hydrogenase

Rosario Scopelliti, Xile Hu, Matthew Wodrich, Tao Xu, Simona Mazza

[Fe]-Hydrogenase catalyzes the hydrogenation of a biological substrate via the heterolytic splitting of molecular hydrogen. While many synthetic models of [Fe]-hydrogenase have been prepared, none yet are capable of activating H-2 on their own. Here, we re ...

American Chemical Society2016

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