Publications associées à Thrombocyte

Acute TNF alpha levels predict cognitive impairment 6-9 months after COVID-19 infection

Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Alexandre Cionca, Idris Guessous

Background: A neurocognitive phenotype of post-COVID-19 infection has recently been described that is characterized by a lack of awareness of memory impairment (i.e., anosognosia), altered functional connectivity in the brain's default mode and limbic netw ...

PERGAMON-ELSEVIER SCIENCE LTD2023

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Jérome Feige, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

How Vibrio cholerae adapts to the environment: from cell shape transitions to antagonistic behavior

Leonardo Filipe Lemos Rocha

The bacterium Vibrio cholerae is the causative agent of the diarrheal disease cholera, which affects millions of people every year. Apart from being a human pathogen, V. cholerae is also a common member of aquatic habitats. Whilst the mechanism that allow ...

EPFL2022

Novel trehalose-based excipients for stabilizing nebulized anti-SARS-CoV-2 antibody

Sandrine Gerber, François Rémi Pierre Noverraz, Solène Marcelle Françoise Marie Passemard

COVID-19 is caused by the infection of the lungs by SARS-CoV-2. Monoclonal antibodies, such as sotrovimab, showed great efficiency in neutralizing the virus before its internalization by lung epithelial cells. However, parenteral routes are still the prefe ...

2023

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration

Hilal Lashuel, Sonia Donzelli

Alteration to endoplasmic reticulum (ER) proteostasis is observed in a variety of neurodegenerative diseases associated with abnormal protein aggregation. Activation of the unfolded protein response (UPR) enables an adaptive reaction to recover ER proteost ...

2021

S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca2+ signaling by Jurkat T cell receptors at the immune synapse

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel a ...

eLIFE SCIENCES PUBL LTD2021

Crystalline poly(triazine imide) membranes and uses thereof

Kumar Varoon Agrawal, Luis Francisco Villalobos Vazquez de la Parra

The invention relates to methods for the preparation of highly crystalline poly(triazine imide) in the form of platelets, atom-thick layers or membranes thereof and resulting products thereof, in particular useful for the preparation of gas separation memb ...

2021

Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate

Nikolaos Stergiopoulos, Augusto Martins Lima, Tom Yohan Abraham Lachkar, François Cuenot, Cindy Marie Elodie Khawand, Damian Salim Saint Auguste

Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and s ...

2020

Attenuation of Lamb Modes and SH Waves near cut-off Frequencies

Soumya Yandrapalli, Victor Plessky

Near cut-off frequencies, the shear horizontal (SH) and Lamb modes in a platelet are created by a bulk acoustic wave bouncing up and down between the platelet sides in an almost vertical direction. The small inclination angle corresponds to slow drift of e ...

IEEE2020

Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs

Christian Heinis, Xudong Kong, Jonas Alfred Karl Wilbs, Simon Jan Middendorp, Patrick Andreas Gonschorek, Christina Lamers

Inhibiting thrombosis without generating bleeding risks is a major challenge in medicine. A promising solution may be the inhibition of coagulation factor XII (FXII), because its knock-out or inhibition in animals reduced thrombosis without causing abnorma ...

Nature Research2020