Concept

Polygène

Publications associées (35)

Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics

Hypertension is a major health problem of largely unknown genetic origins. To identify new genes responsible for hypertension, genetic analysis of recombinant inbred strains of mice followed by human association studies might prove powerful and was exploit ...

Public Library of Science2009

Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

Denis Duboule

During the development of mammalian digits, clustered Hoxd genes are expressed following a collinear regulatory strategy, leading to both the growth of digits and their morphological identities. Because gene dosage is a key parameter in this system, we use ...

2008

MADAP, a flexible clustering tool for the interpretation of one-dimensional genome annotation data

Philipp Bucher

A recurring task in the analysis of mass genome annotation data from high-throughput technologies is the identification of peaks or clusters in a noisy signal profile. Examples of such applications are the definition of promoters on the basis of transcript ...

2007

Automated Parameterization and Patching of Bifurcating Vessels

Recent developments in computational modeling of human arteries have opened the possibility of performing subject-specific analyses on increasingly larger numbers of subjects. This achievement will eventually lead to a better understanding of the role of g ...

2003

A nested deletion approach to generate Cre deleter mice with progressive Hox profiles

Denis Duboule

In mice, the loxP/Cre recombinase-dependent system of recombination offers powerful possibilities for engineering genetic configurations of interest. This system can also be advantageously used for conditional mutagenesis in vivo, whenever such an approach ...

2002

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